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Tfdp1 Gene Detail
Summary
  • Symbol
    Tfdp1
  • Name
    transcription factor Dp 1
  • Synonyms
    Dp1, Drtf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101934
    NCBI Gene: 21781
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:13388751-13428448 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.78 cM, cytoband A1-A3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1081 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101934
 protein coding gene Chr8:13388273-13428448 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033378
 protein coding gene Chr8:10684064-10724314 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0033289
 protein coding gene Chr8:10578575-10621434 (+)
BALB/cJ MGP_BALBcJ_G0033359
 protein coding gene Chr8:10428967-10468511 (+)
C3H/HeJ MGP_C3HHeJ_G0033072
 protein coding gene Chr8:10789964-10831529 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033871
 protein coding gene Chr8:11054543-11098024 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0032394
 protein coding gene Chr8:10550269-10591573 (+)
CBA/J MGP_CBAJ_G0033045
 protein coding gene Chr8:11525877-11567031 (+)
DBA/2J MGP_DBA2J_G0033198
 protein coding gene Chr8:10244278-10285943 (+)
FVB/NJ MGP_FVBNJ_G0033147
 protein coding gene Chr8:10259843-10298626 (+)
LP/J MGP_LPJ_G0033292
 protein coding gene Chr8:10594858-10636264 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033181
 protein coding gene Chr8:11749008-11785933 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033888
 protein coding gene Chr8:10640811-10680480 (+)
PWK/PhJ MGP_PWKPhJ_G0032107
 protein coding gene Chr8:10296305-10338394 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031949
 protein coding gene Chr8:10527402-10565089 (+)
WSB/EiJ MGP_WSBEiJ_G0032510
 protein coding gene Chr8:10671064-10713027 (+)



Homology
more
  • Human Ortholog
    TFDP1, transcription factor Dp-1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFDP1, transcription factor Dp-1
  • Synonyms
    DILC, Dp-1, DP1, DRTF1
  • Links
    NCBI Gene ID: 7027
    neXtProt AC: NX_Q14186
    UniProt: Q14186

  • Chr Location
    13q34; chr13:113584688-113641473 (+)  GRCh38
  • Human Ortholog
    TFDP3, transcription factor Dp family member 3
  • Synonyms
    CT30, DP4, HCA661
  • Links
    NCBI Gene ID: 51270
    neXtProt AC: NX_Q5H9I0
    UniProt: Q5H9I0

  • Chr Location
    Xq26.2; chrX:133216662-133218354 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TFDP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced expansion of the ectoplacental cone and chorion, small yolk sacs, and impaired endoreduplication in trophoblast giant cells. Mutants die by embryonic day 12.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1019
  • Tissues
    233
  • cDNA Data
    108
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038482 Ensembl Gene Model | MGI Sequence Detail 39698 C57BL/6J ±  kb
    transcript ENSMUST00000209885 Ensembl | MGI Sequence Detail 2511 Not Applicable  
    polypeptide ENSMUSP00000147881 Ensembl | MGI Sequence Detail 410 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000016269 transcription factor Dp-1
      (term hierarchy)
    • InterPro Domains
      IPR003316 E2F/DP family, winged-helix DNA-binding domain
      IPR037241 E2F-DP heterodimerization region
      IPR015648 Transcription factor DP
      IPR014889 Transcription factor DP, C-terminal
      IPR038168 Transcription factor DP, C-terminal domain superfamily
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      Q08639 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 120
      Genomic 4
      cDNA 111
      Primer pair 2
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-18766
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 22
      Gene Ontology 12
      Phenotypes 8
    • Earliest
      J:17080 Girling R, et al., A new component of the transcription factor DRTF1/E2F [published erratum appears in Nature 1993 Sep 30;365(6445):468]. Nature. 1993 Mar 4;362(6415):83-7
    • Latest
      J:323190 Guo T, et al., KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. Elife. 2022 Feb 25;11:e74595
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory