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Cd36 Gene Detail
Summary
  • Symbol
    Cd36
  • Name
    CD36 molecule
  • Synonyms
    FAT, fatty acid translocase, Scarb3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107899
    NCBI Gene: 12491
  • Alliance
    gene page
  • Transcription Start Sites
    72 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:17986688-18093799 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 8.11 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3165 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107899
 protein coding gene Chr5:17986680-18093828 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029306
 protein coding gene Chr5:15181461-15287515 (-)
A/J MGP_AJ_G0029271
 protein coding gene Chr5:14718386-14821283 (-)
AKR/J MGP_AKRJ_G0029222
 protein coding gene Chr5:15330833-15436534 (-)
BALB/cJ MGP_BALBcJ_G0029283
 protein coding gene Chr5:15141158-15253748 (-)
C3H/HeJ MGP_C3HHeJ_G0029002
 protein coding gene Chr5:15336866-15450406 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029736
 protein coding gene Chr5:16469833-16584935 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026975
 protein coding gene Chr5:12998926-13098211 (-)
CAST/EiJ MGP_CASTEiJ_G0028414
 protein coding gene Chr5:14678545-14785049 (-)
CBA/J MGP_CBAJ_G0028969
 protein coding gene Chr5:16506261-16629249 (-)
DBA/2J MGP_DBA2J_G0029121
 protein coding gene Chr5:15016583-15123433 (-)
FVB/NJ MGP_FVBNJ_G0029079
 protein coding gene Chr5:14436078-14542108 (-)
LP/J MGP_LPJ_G0029205
 protein coding gene Chr5:15608406-15714800 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029107
 protein coding gene Chr5:17607832-17734935 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029769
 protein coding gene Chr5:14973338-15088195 (-)
PWK/PhJ MGP_PWKPhJ_G0028136
 protein coding gene Chr5:14052405-14162463 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027969
 protein coding gene Chr5:14332052-14436980 (-)
WSB/EiJ MGP_WSBEiJ_G0028494
 protein coding gene Chr5:14975209-15088798 (-)



Homology
more
  • Human Ortholog
    CD36, CD36 molecule (CD36 blood group)
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD36, CD36 molecule (CD36 blood group)
  • Synonyms
    BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3
  • Links
    NCBI Gene ID: 948
    neXtProt AC: NX_P16671
    UniProt: P16671

  • Chr Location
    7q21.11; chr7:80369575-80679277 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cd36 mouse models; 8 with human CD36 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    107 phenotypes from 5 alleles in 9 genetic backgrounds
    8 phenotypes from multigenic genotypes
    292 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit an immunodeficiency phenotype, are susceptible to S. aureus infection and develop ocular pterygium. Mice homozygous for disruptions in this gene display abnormal lipid homeostasis which affects energy utilization in the heart.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    180
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    34
  • cDNA Data
    17
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002944 Ensembl Gene Model | MGI Sequence Detail 107112 C57BL/6J ±  kb
    transcript ENSMUST00000165232 Ensembl | MGI Sequence Detail 2708 Not Applicable  
    polypeptide ENSMUSP00000126300 Ensembl | MGI Sequence Detail 472 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 18
      Primer pair 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36478
    References
    more
    • Summaries
      All 438
      Developmental Gene Expression 26
      Diseases 2
      Gene Ontology 31
      Phenotypes 292
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:355268 Huang Y, et al., The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway. J Lipid Res. 2024 Jan;65(1):100472
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory