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Spata18 Gene Detail
Summary
  • Symbol
    Spata18
  • Name
    spermatogenesis associated 18
  • Synonyms
    1700067I02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920722
    NCBI Gene: 73472
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:73808722-73836855 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 39.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    768 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920722
 protein coding gene Chr5:73808722-73836927 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029629
 protein coding gene Chr5:73665531-73693663 (+)
A/J MGP_AJ_G0029597
 protein coding gene Chr5:70901285-70930467 (+)
AKR/J MGP_AKRJ_G0029545
 protein coding gene Chr5:73204886-73233070 (+)
BALB/cJ MGP_BALBcJ_G0029606
 protein coding gene Chr5:71613707-71642349 (+)
C3H/HeJ MGP_C3HHeJ_G0029329
 protein coding gene Chr5:73601615-73635962 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030060
 protein coding gene Chr5:76700563-76728857 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027300
 protein coding gene Chr5:66581754-66609884 (+)
CAST/EiJ MGP_CASTEiJ_G0028737
 protein coding gene Chr5:72670432-72700694 (+)
CBA/J MGP_CBAJ_G0029298
 protein coding gene Chr5:79211885-79240090 (+)
DBA/2J MGP_DBA2J_G0029443
 protein coding gene Chr5:70984554-71012866 (+)
FVB/NJ MGP_FVBNJ_G0029404
 protein coding gene Chr5:70126351-70154476 (+)
LP/J MGP_LPJ_G0029529
 protein coding gene Chr5:74110444-74138556 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029431
 protein coding gene Chr5:82484488-82513812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030093
 protein coding gene Chr5:72739293-72767412 (+)
PWK/PhJ MGP_PWKPhJ_G0028460
 protein coding gene Chr5:69952878-69984568 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028295
 protein coding gene Chr5:72093108-72121711 (+)
WSB/EiJ MGP_WSBEiJ_G0028817
 protein coding gene Chr5:73041881-73070941 (+)



Homology
more
  • Human Ortholog
    SPATA18, spermatogenesis associated 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPATA18, spermatogenesis associated 18
  • Synonyms
    Mieap, SPETEX1
  • Links
    NCBI Gene ID: 132671
    neXtProt AC: NX_Q8TC71
    UniProt: Q8TC71

  • Chr Location
    4q12
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from multigenic genotypes
    362 phenotype references
Homo- or heterozygous KO in mice also carrying one copy of the ApcMin allele leads to increased intestinal adenoma and adenocarcinoma tumor incidence and size. This double mutation and homozygous KO of the gene alone results in lower internal mitochondrial cristae density in small intestinal mucosal epithelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029155 Ensembl Gene Model | MGI Sequence Detail 28134 C57BL/6J ±  kb
transcript ENSMUST00000071077 Ensembl | MGI Sequence Detail 1978 Not Applicable  
polypeptide ENSMUSP00000064308 Ensembl | MGI Sequence Detail 537 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 387
    Diseases 1
    Gene Ontology 7
    Phenotypes 362
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory