Cep126 MGI Mouse Gene Detail - MGI:2680221

Symbol

Cep126
Name

centrosomal protein 126
Synonyms

AK129341, mKIAA1377

Feature Type

protein coding gene
IDs

MGI:2680221
NCBI Gene: 234915
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:8076462-8134295 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 2.46 cM
Mapping Data

1 experiment

SNPs within 2kb

1532 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2680221	protein coding gene	Chr9:8076461-8134473 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034333	protein coding gene	Chr9:4973086-5036050 (-)
A/J	MGP_AJ_G0034311	protein coding gene	Chr9:5060357-5120297 (-)
AKR/J	MGP_AKRJ_G0034239	protein coding gene	Chr9:4933172-4995978 (-)
BALB/cJ	MGP_BALBcJ_G0034305	protein coding gene	Chr9:4790083-4865506 (-)
C3H/HeJ	MGP_C3HHeJ_G0034016	protein coding gene	Chr9:5111798-5175518 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034827	protein coding gene	Chr9:5143808-5202583 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031765	protein coding gene	Chr9:4286065-4339299 (-)
CAST/EiJ	MGP_CASTEiJ_G0033344	protein coding gene	Chr9:5128961-5187360 (-)
CBA/J	MGP_CBAJ_G0033989	protein coding gene	Chr9:5316326-5382310 (-)
DBA/2J	MGP_DBA2J_G0034146	protein coding gene	Chr9:4932190-4989708 (-)
FVB/NJ	MGP_FVBNJ_G0034091	protein coding gene	Chr9:4700465-4761432 (-)
LP/J	MGP_LPJ_G0034232	protein coding gene	Chr9:5002833-5068623 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034135	protein coding gene	Chr9:6016803-6108511 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034846	protein coding gene	Chr9:4939531-5001990 (-)
PWK/PhJ	MGP_PWKPhJ_G0033047	protein coding gene	Chr9:5046476-5107977 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032885	protein coding gene	Chr9:5166770-5230755 (-)
WSB/EiJ	MGP_WSBEiJ_G0033459	protein coding gene	Chr9:4964602-5023392 (-)

Human Ortholog

CEP126, centrosomal protein 126

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEP126, centrosomal protein 126
Synonyms

KIAA1377
Links

HGNC:29264

NCBI Gene ID: 57562

neXtProt AC: NX_Q9P2H0

UniProt: Q9P2H0
Chr Location

11q22.1; chr11:101915010-102001062 (+) GRCh38

MGI Vertebrate Homology

Cep126 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CEP126
Gene Tree

Cep126

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

19
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

786
Tissues

38
cDNA Data

9
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cep126

ZFIN cep126

less

All Sequences

53
RefSeq

18
UniProt

2
CCDS

CCDS40534.1

Ensembl

ENSMUSG00000040729 (Evidence)
NCBI Gene

234915

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040729	Ensembl Gene Model \| MGI Sequence Detail	57834	C57BL/6J	± kb
transcript	ENSMUST00000037397	Ensembl \| MGI Sequence Detail	3819	Not Applicable
polypeptide	ENSMUSP00000042904	Ensembl \| MGI Sequence Detail	1103	Not Applicable

less

UniProt

2 Sequences
InterPro Domains

IPR028257 Centrosomal protein of 126kDa

less

All nucleic 9

cDNA 9

Microarray probesets 3

Summaries

All 30

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 5
Earliest

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cep126:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88120	Chr9:8134429-8134481 (-)	-160 bp
Tssr88119	Chr9:8134352-8134365 (-)	-64 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24