Fut7 MGI Mouse Gene Detail - MGI:107692

Symbol

Fut7
Name

fucosyltransferase 7
Synonyms

FTVII, Fuc-TVII, FucT-VII

Feature Type

protein coding gene
IDs

MGI:107692
NCBI Gene: 14347
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:25313279-25316386 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 17.25 cM
Mapping Data

1 experiment

SNPs within 2kb

132 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107692	protein coding gene	Chr2:25312363-25316386 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025445	protein coding gene	Chr2:23311768-23314875 (+)
A/J	MGP_AJ_G0025422	protein coding gene	Chr2:22406833-22409940 (+)
AKR/J	MGP_AKRJ_G0025392	protein coding gene	Chr2:23155847-23158954 (+)
BALB/cJ	MGP_BALBcJ_G0025418	protein coding gene	Chr2:22520484-22523591 (+)
C3H/HeJ	MGP_C3HHeJ_G0025179	protein coding gene	Chr2:23093949-23097056 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025862	protein coding gene	Chr2:24058080-24061187 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023273	protein coding gene	Chr2:21318574-21321695 (+)
CAST/EiJ	MGP_CASTEiJ_G0024642	protein coding gene	Chr2:22973097-22976193 (+)
CBA/J	MGP_CBAJ_G0025157	protein coding gene	Chr2:24891676-24894783 (+)
DBA/2J	MGP_DBA2J_G0025290	protein coding gene	Chr2:22246736-22249843 (+)
FVB/NJ	MGP_FVBNJ_G0025252	protein coding gene	Chr2:21991461-21994568 (+)
LP/J	MGP_LPJ_G0025376	protein coding gene	Chr2:23253051-23256158 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025283	protein coding gene	Chr2:25081480-25084587 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025921	protein coding gene	Chr2:23109551-23112658 (+)
PWK/PhJ	MGP_PWKPhJ_G0024390	protein coding gene	Chr2:22068829-22071942 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024190	protein coding gene	Chr2:23251916-23255020 (+)
WSB/EiJ	MGP_WSBEiJ_G0024711	protein coding gene	Chr2:23186205-23189312 (+)

Human Ortholog

FUT7, fucosyltransferase 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FUT7, fucosyltransferase 7
Synonyms

FucT-VII
Links

HGNC:4018

NCBI Gene ID: 2529

neXtProt AC: NX_Q11130

UniProt: Q11130
Chr Location

9q34.3; chr9:137030174-137032088 (-) GRCh38

MGI Vertebrate Homology

Fut7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FUT7
Gene Tree

Fut7

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Phenotype Summary

15 phenotypes from 2 alleles in 3 genetic backgrounds
13 phenotypes from multigenic genotypes
61 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Targeted

6
Incidental Mutations

APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene are superficially normal. However, abnormalities are found in immune cell function and lymph node morphology. Redeuced tumor metastasis is also seen.

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All GO Annotations

50
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

14
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fut7

ZFIN fut7

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All Sequences

69
RefSeq

22
UniProt

4
CCDS

CCDS15772.1, CCDS50530.1

Ensembl

ENSMUSG00000036587 (Evidence)
NCBI Gene

14347

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036587	Ensembl Gene Model \| MGI Sequence Detail	3108	C57BL/6J	± kb
transcript	ENSMUST00000100320	Ensembl \| MGI Sequence Detail	2076	Not Applicable
polypeptide	ENSMUSP00000097895	Ensembl \| MGI Sequence Detail	389	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000030635 alpha-(1,3)-fucosyltransferase 7

(term hierarchy)
EC

2.4.1.-
InterPro Domains

IPR031481 Fucosyltransferase, N-terminal

IPR001503 Glycosyl transferase family 10

IPR038577 GT10-like, C-terminal domain superfamily
GlyGen

Q11131 2 sites

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All nucleic 18

Genomic 3

cDNA 14

Primer pair 1

Microarray probesets 3

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MGD-MRK-36268, MGI:2139093

Summaries

All 93

Developmental Gene Expression 2

Gene Ontology 13

Phenotypes 61
Earliest

J:32202 Smith PL, et al., Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands. J Biol Chem. 1996 Apr 5;271(14):8250-9
Latest

J:340815 Liu W, et al., A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans attenuates murine allergic rhinitis by suppressing Th2 immune responses. Sci Rep. 2023 Sep 21;13(1):15740

TSS for Fut7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16714	Chr2:25313246-25313262 (+)	-25 bp
Tssr16715	Chr2:25314644-25314685 (+)	1,386 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24