Relch MGI Mouse Gene Detail - MGI:1922832 - RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing

Symbol

Relch
Name

RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms

2310035C23Rik

Feature Type

protein coding gene
IDs

MGI:1922832
NCBI Gene: 227446
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:105591570-105682856 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 49.64 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

1717 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922832	protein coding gene	Chr1:105591570-105682916 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016367	protein coding gene	Chr1:107771942-107875350 (+)
A/J	MGP_AJ_G0016351	protein coding gene	Chr1:104023316-104114868 (+)
AKR/J	MGP_AKRJ_G0016311	protein coding gene	Chr1:106874007-106968993 (+)
BALB/cJ	MGP_BALBcJ_G0016307	protein coding gene	Chr1:104114848-104206163 (+)
C3H/HeJ	MGP_C3HHeJ_G0016134	protein coding gene	Chr1:107311483-107407051 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016766	protein coding gene	Chr1:111923929-112022207 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014484	protein coding gene	Chr1:98374361-98463728 (+)
CAST/EiJ	MGP_CASTEiJ_G0015716	protein coding gene	Chr1:106217612-106313441 (+)
CBA/J	MGP_CBAJ_G0016107	protein coding gene	Chr1:115719699-115818333 (+)
DBA/2J	MGP_DBA2J_G0016212	protein coding gene	Chr1:103086619-103178454 (+)
FVB/NJ	MGP_FVBNJ_G0016213	protein coding gene	Chr1:102025624-102120660 (+)
LP/J	MGP_LPJ_G0016286	protein coding gene	Chr1:109047783-109142616 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016239	protein coding gene	Chr1:120182028-120292264 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016805	protein coding gene	Chr1:106953027-107047192 (+)
PWK/PhJ	MGP_PWKPhJ_G0015503	protein coding gene	Chr1:102127943-102219937 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015288	protein coding gene	Chr1:105613577-105702748 (+)
WSB/EiJ	MGP_WSBEiJ_G0015779	protein coding gene	Chr1:106790142-106884349 (+)

Human Ortholog

RELCH, RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RELCH, RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms

HsT3308, HsT885, KIAA1468
Links

HGNC:29289

NCBI Gene ID: 57614

neXtProt AC: NX_Q9P260

UniProt: Q9P260
Chr Location

18q21.33; chr18:62187255-62310249 (+) GRCh38

MGI Vertebrate Homology

Relch stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RELCH
Gene Tree

Relch

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

13
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Relch
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

83 strains or lines available

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

9
cDNA Data

89
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase relch

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All Sequences

108
RefSeq

42
UniProt

8
CCDS

CCDS15206.1, CCDS48334.1

Ensembl

ENSMUSG00000026319 (Evidence)
NCBI Gene

227446

			Length	Strain/Species	Flank
genomic	227446	NCBI Gene Model \| MGI Sequence Detail	91287	C57BL/6J	± kb
transcript	NM_173187	RefSeq \| MGI Sequence Detail	5406	C57BL/6
polypeptide	Q148V7	UniProt \| EBI \| MGI Sequence Detail	1216	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000060125 RAB11-binding protein RELCH

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR021133 HEAT, type 2

IPR006594 LIS1 homology motif

IPR040362 RAB11-binding protein RELCH
GlyGen

Q148V7 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)

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All nucleic 89

cDNA 89

Microarray probesets 9

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MGI:6162262

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Relch:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8261	Chr1:105591580-105591591 (+)	16 bp
Tssr8262	Chr1:105591594-105591645 (+)	50 bp
Tssr8263	Chr1:105597055-105597063 (+)	5,489 bp
Tssr8264	Chr1:105597534-105597537 (+)	5,966 bp
Tssr8265	Chr1:105603375-105603379 (+)	11,807 bp
Tssr8266	Chr1:105605898-105605902 (+)	14,330 bp
Tssr8267	Chr1:105629129-105629133 (+)	37,561 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24