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Gspt2 Gene Detail
Summary
  • Symbol
    Gspt2
  • Name
    G1 to S phase transition 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316727
    NCBI Gene: 14853
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:93679675-93682168 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 41.63 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316727
 protein coding gene ChrX:93679675-93686850 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035913
 protein coding gene ChrX:91062105-91069280 (+)
A/J MGP_AJ_G0035899
 protein coding gene ChrX:91142410-91150660 (+)
AKR/J MGP_AKRJ_G0035816
 protein coding gene ChrX:93552475-93559656 (+)
BALB/cJ MGP_BALBcJ_G0035883
 protein coding gene ChrX:89864541-89871722 (+)
C3H/HeJ MGP_C3HHeJ_G0035592
 protein coding gene ChrX:91416496-91423677 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036412
 protein coding gene ChrX:93840837-93848012 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033239
 protein coding gene ChrX:89283153-89290411 (+)
CAST/EiJ MGP_CASTEiJ_G0034877
 protein coding gene ChrX:76079226-76086458 (+)
CBA/J MGP_CBAJ_G0035566
 protein coding gene ChrX:96542672-96549853 (+)
DBA/2J MGP_DBA2J_G0035722
 protein coding gene ChrX:90367183-90374307 (+)
FVB/NJ MGP_FVBNJ_G0035661
 protein coding gene ChrX:89777552-89784704 (+)
LP/J MGP_LPJ_G0035811
 protein coding gene ChrX:91876906-91884081 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035695
 protein coding gene ChrX:100899425-100906600 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036439
 protein coding gene ChrX:90762437-90769618 (+)
PWK/PhJ MGP_PWKPhJ_G0034576
 protein coding gene ChrX:73844027-73851325 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034406
 protein coding gene ChrX:76941894-76949088 (+)
WSB/EiJ MGP_WSBEiJ_G0035018
 protein coding gene ChrX:89568774-89575955 (+)



Homology
more
  • Human Ortholog
    GSPT2, G1 to S phase transition 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSPT2, G1 to S phase transition 2
  • Synonyms
    ERF3B, GST2
  • Links
    NCBI Gene ID: 23708
    neXtProt AC: NX_Q8IYD1
    UniProt: Q8IYD1

  • Chr Location
    Xp11.22; chrX:51743442-51746232 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    22
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14853 NCBI Gene Model | MGI Sequence Detail 2494 C57BL/6J ±  kb
    transcript NM_008179 RefSeq | MGI Sequence Detail 2508 C57BL/6  
    polypeptide Q149F3 UniProt | EBI | MGI Sequence Detail 632 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008291 eukaryotic peptide chain release factor GTP-binding subunit ERF3B
      (term hierarchy)
    • EC
      3.6.5.-
    • InterPro Domains
      IPR009818 Ataxin-2, C-terminal
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR000795 Translational (tr)-type GTP-binding domain
      IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
      IPR004161 Translation elongation factor EFTu-like, domain 2
      IPR050100 Translation factor GTPase superfamily members
      IPR009000 Translation protein, beta-barrel domain superfamily
      IPR031157 Tr-type G domain, conserved site
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 4
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:49569 Hoshino S, et al., Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. J Biol Chem. 1998 Aug 28;273(35):22254-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory