Cdk12 MGI Mouse Gene Detail - MGI:1098802 - cyclin dependent kinase 12

Symbol

Cdk12
Name

cyclin dependent kinase 12
Synonyms

1810022J16Rik, Crk7, Crkrs, D11Ertd752e

Feature Type

protein coding gene
IDs

MGI:1098802
NCBI Gene: 69131
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:98093885-98169330 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 61.75 cM, cytoband D
Mapping Data

6 experiments

SNPs within 2kb

1566 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098802	protein coding gene	Chr11:98093259-98171941 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019052	protein coding gene	Chr11:100724427-100807018 (+)
A/J	MGP_AJ_G0019020	protein coding gene	Chr11:96550384-96625635 (+)
AKR/J	MGP_AKRJ_G0018990	protein coding gene	Chr11:99535172-99612654 (+)
BALB/cJ	MGP_BALBcJ_G0018993	protein coding gene	Chr11:97040084-97116010 (+)
C3H/HeJ	MGP_C3HHeJ_G0018807	protein coding gene	Chr11:99664975-99743129 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019446	protein coding gene	Chr11:103809272-103888752 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017077	protein coding gene	Chr11:93987374-94063783 (+)
CAST/EiJ	MGP_CASTEiJ_G0018361	protein coding gene	Chr11:100538480-100617961 (+)
CBA/J	MGP_CBAJ_G0018778	protein coding gene	Chr11:108119991-108202066 (+)
DBA/2J	MGP_DBA2J_G0018886	protein coding gene	Chr11:96090177-96165728 (+)
FVB/NJ	MGP_FVBNJ_G0018875	protein coding gene	Chr11:95596097-95672203 (+)
LP/J	MGP_LPJ_G0018956	protein coding gene	Chr11:101202640-101283482 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018902	protein coding gene	Chr11:107924325-108005577 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019486	protein coding gene	Chr11:99863119-99942986 (+)
PWK/PhJ	MGP_PWKPhJ_G0018133	protein coding gene	Chr11:97091356-97169804 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017923	protein coding gene	Chr11:99568983-99646878 (+)
WSB/EiJ	MGP_WSBEiJ_G0018411	protein coding gene	Chr11:99767035-99847721 (+)

Human Ortholog

CDK12, cyclin dependent kinase 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK12, cyclin dependent kinase 12
Synonyms

CRK7, CRKR, CRKRS
Links

HGNC:24224

NCBI Gene ID: 51755

neXtProt AC: NX_Q9NYV4

UniProt: Q9NYV4
Chr Location

17q12; chr17:39461486-39567559 (+) GRCh38

MGI Vertebrate Homology

Cdk12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDK12
Gene Tree

Cdk12

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Phenotype Summary

21 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

4
Gene trapped

17
Targeted

6
Genomic Mutations

1 involving Cdk12
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

75 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit lethality between implantation and E6.5 with decreased proliferation and increased apoptosis in the inner cell mass.

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All GO Annotations

44
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

32
cDNA Data

20
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDK12

Xenbase cdk12

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All Sequences

83
RefSeq

27
UniProt

3
CCDS

CCDS25342.1, CCDS48901.1, CCDS48902.1

Ensembl

ENSMUSG00000003119 (Evidence)
NCBI Gene

69131

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003119	Ensembl Gene Model \| MGI Sequence Detail	75446	C57BL/6J	± kb
transcript	ENSMUST00000107538	Ensembl \| MGI Sequence Detail	5143	Not Applicable
polypeptide	ENSMUSP00000103162	Ensembl \| MGI Sequence Detail	1484	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005884 cyclin-dependent kinase 12

(term hierarchy)
EC

2.7.11.22, 2.7.11.23
InterPro Domains

IPR050108 Cyclin-dependent kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q14AX6 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 24

cDNA 21

Primer pair 2

Other 1

Microarray probesets 10

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MGI:1289232, MGI:1916381, MGI:2144249

Summaries

All 61

Developmental Gene Expression 4

Gene Ontology 12

Phenotypes 24
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdk12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104704	Chr11:98093564-98093575 (+)	-315 bp
Tssr104705	Chr11:98093584-98093627 (+)	-279 bp
Tssr104706	Chr11:98093641-98093646 (+)	-241 bp
Tssr104707	Chr11:98094133-98094174 (+)	269 bp
Tssr104708	Chr11:98101622-98101654 (+)	7,753 bp
Tssr104709	Chr11:98108032-98108038 (+)	14,150 bp
Tssr104710	Chr11:98139141-98139147 (+)	45,259 bp
Tssr104711	Chr11:98143899-98143904 (+)	50,017 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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