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Grm2 Gene Detail
Summary
  • Symbol
    Grm2
  • Name
    glutamate receptor, metabotropic 2
  • Synonyms
    4930441L02Rik, Gprc1b, mGluR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351339
    NCBI Gene: 108068
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106521733-106533308 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 57.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    310 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351339
 protein coding gene Chr9:106520294-106533308 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035241
 protein coding gene Chr9:108459354-108472295 (-)
A/J MGP_AJ_G0035220
 protein coding gene Chr9:104528508-104541453 (-)
AKR/J MGP_AKRJ_G0035152
 protein coding gene Chr9:107136528-107149473 (-)
BALB/cJ MGP_BALBcJ_G0035214
 protein coding gene Chr9:104215191-104228152 (-)
C3H/HeJ MGP_C3HHeJ_G0034924
 protein coding gene Chr9:107550066-107564513 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035734
 protein coding gene Chr9:111451289-111464214 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032632
 protein coding gene Chr9:102015548-102028495 (-)
CAST/EiJ MGP_CASTEiJ_G0034235
 protein coding gene Chr9:107468871-107481941 (-)
CBA/J MGP_CBAJ_G0034892
 protein coding gene Chr9:115404065-115417065 (-)
DBA/2J MGP_DBA2J_G0035053
 protein coding gene Chr9:103993563-104006743 (-)
FVB/NJ MGP_FVBNJ_G0035001
 protein coding gene Chr9:102773179-102786130 (-)
LP/J MGP_LPJ_G0035129
 protein coding gene Chr9:108674113-108687062 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035040
 protein coding gene Chr9:116976773-116989720 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035755
 protein coding gene Chr9:107398961-107411906 (-)
PWK/PhJ MGP_PWKPhJ_G0033942
 protein coding gene Chr9:104296711-104309968 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033777
 protein coding gene Chr9:107470328-107486244 (-)
WSB/EiJ MGP_WSBEiJ_G0034356
 protein coding gene Chr9:107300626-107313608 (-)



Homology
more
  • Human Ortholog
    GRM2, glutamate metabotropic receptor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRM2, glutamate metabotropic receptor 2
  • Synonyms
    GLUR2, GPRC1B, mGlu2, MGLUR2
  • Links
    NCBI Gene ID: 2912
    neXtProt AC: NX_Q14416
    UniProt: Q14416

  • Chr Location
    3p21.2; chr3:51707068-51718613 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display subtile behavioral modifications and moderate abnormalities in long term depression and EPSP in the hippocampus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    42
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    8
  • cDNA Data
    5
  • Literature Summary
    15
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 108068 NCBI Gene Model | MGI Sequence Detail 11576 C57BL/6J ±  kb
transcript NM_001160353 RefSeq | MGI Sequence Detail 3338 C57BL/6  
polypeptide Q14BI2 UniProt | EBI | MGI Sequence Detail 872 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008264 metabotropic glutamate receptor 2
    (term hierarchy)
  • InterPro Domains
    IPR000337 GPCR, family 3
    IPR017979 GPCR, family 3, conserved site
    IPR017978 GPCR family 3, C-terminal
    IPR000162 GPCR, family 3, metabotropic glutamate receptor
    IPR001458 GPCR, family 3, metabotropic glutamate receptor 2
    IPR011500 GPCR, family 3, nine cysteines domain
    IPR038550 GPCR, family 3, nine cysteines domain superfamily
    IPR050726 Metabotropic Glutamate Receptor
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
  • GlyGen
    Q14BI2 7 sites, 5 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 9
    Genomic 2
    cDNA 6
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10265, MGI:1921233, MGI:95826
References
more
  • Summaries
    All 95
    Developmental Gene Expression 15
    Gene Ontology 13
    Phenotypes 38
  • Earliest
    J:18132 Thomsen C, et al., (S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem. 1994 Jun;62(6):2492-5
  • Latest
    J:353074 Busceti CL, et al., Adaptive Changes in Group 2 Metabotropic Glutamate Receptors Underlie the Deficit in Recognition Memory Induced by Methamphetamine in Mice. eNeuro. 2024 Aug;11(8):ENEURO.0523-23.2024
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory