Tdrd9 MGI Mouse Gene Detail - MGI:1921941 - tudor domain containing 9

Symbol

Tdrd9
Name

tudor domain containing 9
Synonyms

4930441E05Rik

Feature Type

protein coding gene
IDs

MGI:1921941
NCBI Gene: 74691
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:111937993-112035288 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 61.14 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

2808 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921941	protein coding gene	Chr12:111937922-112035288 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020146	protein coding gene	Chr12:114408217-114500975 (+)
A/J	MGP_AJ_G0020102	protein coding gene	Chr12:110002791-110090241 (+)
AKR/J	MGP_AKRJ_G0020077	protein coding gene	Chr12:113169629-113266391 (+)
BALB/cJ	MGP_BALBcJ_G0020087	protein coding gene	Chr12:110421142-110513227 (+)
C3H/HeJ	MGP_C3HHeJ_G0019889	protein coding gene	Chr12:113659088-113754687 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020532	protein coding gene	Chr12:117959174-118052842 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018145	protein coding gene	Chr12:106432998-106525917 (+)
CAST/EiJ	MGP_CASTEiJ_G0019430	protein coding gene	Chr12:108510187-108608496 (+)
CBA/J	MGP_CBAJ_G0019856	protein coding gene	Chr12:122463316-122563332 (+)
DBA/2J	MGP_DBA2J_G0019973	protein coding gene	Chr12:109479965-109575161 (+)
FVB/NJ	MGP_FVBNJ_G0019958	protein coding gene	Chr12:108290260-108379099 (+)
LP/J	MGP_LPJ_G0020048	protein coding gene	Chr12:114231494-114326332 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019996	protein coding gene	Chr12:125556832-125656728 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020561	protein coding gene	Chr12:112678843-112772743 (+)
PWK/PhJ	MGP_PWKPhJ_G0019191	protein coding gene	Chr12:104128955-104216892 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018994	protein coding gene	Chr12:106835738-106931190 (+)
WSB/EiJ	MGP_WSBEiJ_G0019489	protein coding gene	Chr12:113584870-113677100 (+)

Human Ortholog

TDRD9, tudor domain containing 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TDRD9, tudor domain containing 9
Synonyms

C14orf75, HIG-1, HLS, NET54, SPGF30, SPNE
Links

HGNC:20122

NCBI Gene ID: 122402

neXtProt AC: NX_Q8NDG6

UniProt: Q8NDG6
Chr Location

14q32.33; chr14:103928456-104052667 (+) GRCh38

MGI Vertebrate Homology

Tdrd9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TDRD9
Gene Tree

Tdrd9

Diseases

1 with human TDRD9 associations

				Human Disease	Mouse Models
				spermatogenic failure 30 IDs spermatogenic failure 30 DOID:0111913 OMIM:618110

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

73 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male homozygous mice are sterile, displaying small testis, arrest of male meiosis and abnormal spermatocyte morphology. Females are fertile.

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All GO Annotations

29
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

2
cDNA Data

17
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tdrd9

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All Sequences

54
RefSeq

18
UniProt

3
CCDS

CCDS49184.1

Ensembl

ENSMUSG00000054003 (Evidence)
NCBI Gene

74691

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054003	Ensembl Gene Model \| MGI Sequence Detail	97296	C57BL/6J	± kb
transcript	ENSMUST00000079009	Ensembl \| MGI Sequence Detail	4809	Not Applicable
polypeptide	ENSMUSP00000078022	Ensembl \| MGI Sequence Detail	1383	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030790 ATP-dependent RNA helicase TDRD9

(term hierarchy)
EC

3.6.4.13
InterPro Domains

IPR011545 DEAD/DEAH box helicase domain

IPR007502 Helicase-associated domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR035437 SNase-like, OB-fold superfamily

IPR002999 Tudor domain

IPR047384 Tudor domain-containing protein 9, Tudor domain
GlyGen

Q14BI7 1 site, 1 O-linked glycan (1 site)

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All nucleic 23

cDNA 17

Primer pair 6

Microarray probesets 2

Summaries

All 39

Developmental Gene Expression 11

Gene Ontology 11

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:330334 Zhang H, et al., The RNA ligase RNA terminal phosphate cyclase B regulates mRNA alternative splicing and is required for mouse oocyte development and maintenance. Development. 2022 Oct 1;149(19):dev200497

TSS for Tdrd9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115360	Chr12:111937979-111938032 (+)	13 bp
Tssr115361	Chr12:111938042-111938053 (+)	55 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24