Gpat2 MGI Mouse Gene Detail - MGI:2684962 - glycerol-3-phosphate acyltransferase 2, mitochondrial

Symbol

Gpat2
Name

glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms

A530057A03Rik, Gpat2

Feature Type

protein coding gene
IDs

MGI:2684962
NCBI Gene: 215456
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:127267119-127278012 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.00 cM
Mapping Data

1 experiment

SNPs within 2kb

258 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684962	protein coding gene	Chr2:127266725-127278013 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026459	protein coding gene	Chr2:130718045-130728925 (+)
A/J	MGP_AJ_G0026423	protein coding gene	Chr2:125412416-125423296 (+)
AKR/J	MGP_AKRJ_G0026398	protein coding gene	Chr2:128994556-129005436 (+)
BALB/cJ	MGP_BALBcJ_G0026435	protein coding gene	Chr2:125680252-125691132 (+)
C3H/HeJ	MGP_C3HHeJ_G0026178	protein coding gene	Chr2:129509386-129520281 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026880	protein coding gene	Chr2:134817232-134828125 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024257	protein coding gene	Chr2:120255132-120265996 (+)
CAST/EiJ	MGP_CASTEiJ_G0025639	protein coding gene	Chr2:129715481-129726472 (+)
CBA/J	MGP_CBAJ_G0026158	protein coding gene	Chr2:139803406-139814301 (+)
DBA/2J	MGP_DBA2J_G0026292	protein coding gene	Chr2:124821726-124832621 (+)
FVB/NJ	MGP_FVBNJ_G0026256	protein coding gene	Chr2:123473444-123484324 (+)
LP/J	MGP_LPJ_G0026397	protein coding gene	Chr2:130945410-130956290 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026276	protein coding gene	Chr2:143826319-143837199 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026935	protein coding gene	Chr2:129019707-129030587 (+)
PWK/PhJ	MGP_PWKPhJ_G0025375	protein coding gene	Chr2:124369109-124380002 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025177	protein coding gene	Chr2:128100500-128111418 (+)
WSB/EiJ	MGP_WSBEiJ_G0025713	protein coding gene	Chr2:129914059-129924952 (+)

Human Ortholog

GPAT2, glycerol-3-phosphate acyltransferase 2, mitochondrial

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPAT2, glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms

CT123
Links

HGNC:27168

NCBI Gene ID: 150763

neXtProt AC: NX_Q6NUI2

UniProt: Q6NUI2
Chr Location

2q11.2; chr2:96021946-96039451 (-) GRCh38

MGI Vertebrate Homology

Gpat2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPAT2
Gene Tree

Gpat2

less

Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Gpat2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility associated with decreased testis weight, impaired spermatogenesis, azoospermia, abnormal DNA methylation during gametogenesis, and increased male germ cell apoptosis.

less

All GO Annotations

16
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

843
Tissues

107
cDNA Data

8
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpat2

ZFIN gpat2

less

All Sequences

50
RefSeq

16
UniProt

2
CCDS

CCDS38232.2

Ensembl

ENSMUSG00000046338 (Evidence)
NCBI Gene

215456

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046338	Ensembl Gene Model \| MGI Sequence Detail	10894	C57BL/6J	± kb
transcript	ENSMUST00000062211	Ensembl \| MGI Sequence Detail	2628	Not Applicable
polypeptide	ENSMUSP00000049619	Ensembl \| MGI Sequence Detail	801	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000008160 glycerol-3-phosphate acyltransferase 2, mitochondrial

(term hierarchy)
EC

2.3.1.15, 2.3.1.51
InterPro Domains

IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase

IPR041728 GPAT/DHAPAT, acyltransferase domain

IPR045520 GPAT/DHAPAT, C-terminal domain

IPR002123 Phospholipid/glycerol acyltransferase

less

All nucleic 10

cDNA 8

Primer pair 2

Microarray probesets 2

Summaries

All 37

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 8
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:307865 Dahlet T, et al., E2F6 initiates stable epigenetic silencing of germline genes during embryonic development. Nat Commun. 2021 Jun 11;12(1):3582

TSS for Gpat2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20020	Chr2:127267075-127267114 (+)	-24 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24