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Ripply2 Gene Detail
Summary
  • Symbol
    Ripply2
  • Name
    ripply transcriptional repressor 2
  • Synonyms
    C030002E08Rik, LOC382089
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685968
    NCBI Gene: 382089
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr9:86897590-86901970 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 46.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    274 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685968
 protein coding gene Chr9:86897590-86902494 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035101
 protein coding gene Chr9:87883901-87888257 (+)
A/J MGP_AJ_G0035082
 protein coding gene Chr9:84803285-84807664 (+)
AKR/J MGP_AKRJ_G0035010
 protein coding gene Chr9:86828850-86833230 (+)
BALB/cJ MGP_BALBcJ_G0035070
 protein coding gene Chr9:84448767-84453146 (+)
C3H/HeJ MGP_C3HHeJ_G0034782
 protein coding gene Chr9:87280137-87284516 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035594
 protein coding gene Chr9:90233729-90238169 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032501
 protein coding gene Chr9:83571276-83575626 (+)
CAST/EiJ MGP_CASTEiJ_G0034100
 protein coding gene Chr9:87742673-87747006 (+)
CBA/J MGP_CBAJ_G0034755
 protein coding gene Chr9:93386099-93390475 (+)
DBA/2J MGP_DBA2J_G0034913
 protein coding gene Chr9:84359721-84364332 (+)
FVB/NJ MGP_FVBNJ_G0034856
 protein coding gene Chr9:83448102-83452481 (+)
LP/J MGP_LPJ_G0034994
 protein coding gene Chr9:88100991-88105355 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034898
 protein coding gene Chr9:95038981-95054004 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035614
 protein coding gene Chr9:86929588-86934007 (+)
PWK/PhJ MGP_PWKPhJ_G0033804
 protein coding gene Chr9:84531549-84535899 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033640
 protein coding gene Chr9:87135354-87139642 (+)
WSB/EiJ MGP_WSBEiJ_G0034217
 protein coding gene Chr9:86968519-86972903 (+)



Homology
more
  • Human Ortholog
    RIPPLY2, ripply transcriptional repressor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RIPPLY2, ripply transcriptional repressor 2
  • Synonyms
    C6orf159, dJ237I15.1, SCDO6
  • Links
    NCBI Gene ID: 134701
    neXtProt AC: NX_Q5TAB7
    UniProt: Q5TAB7

  • Chr Location
    6q14.2; chr6:83853229-83857515 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ripply2 mouse models; 1 with human RIPPLY2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations display neonatal lethality, rib and vertebral abnormalities, impaired somite formation, decreased body length, and short tails.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    13
  • cDNA Data
    3
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047897 Ensembl Gene Model | MGI Sequence Detail 4381 C57BL/6J ±  kb
    transcript ENSMUST00000058846 Ensembl | MGI Sequence Detail 503 Not Applicable  
    polypeptide ENSMUSP00000055369 Ensembl | MGI Sequence Detail 128 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 4
      Primer pair 1
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:104947 Kawamura A, et al., Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites. Dev Cell. 2005 Dec;9(6):735-44
    • Latest
      J:346126 Pappas MP, et al., Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm. Development. 2024 Mar 1;151(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory