Acsbg2 MGI Mouse Gene Detail - MGI:3587728 - acyl-CoA synthetase bubblegum family member 2

Symbol

Acsbg2
Name

acyl-CoA synthetase bubblegum family member 2
Synonyms

Bgr

Feature Type

protein coding gene
IDs

MGI:3587728
NCBI Gene: 328845
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:57150103-57181447 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 29.54 cM
Mapping Data

1 experiment

SNPs within 2kb

1000 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3587728	protein coding gene	Chr17:57150103-57181505 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023941	protein coding gene	Chr17:58575196-58610464 (-)
A/J	MGP_AJ_G0023899	protein coding gene	Chr17:56960315-56992686 (-)
AKR/J	MGP_AKRJ_G0023868	protein coding gene	Chr17:57678954-57712183 (-)
BALB/cJ	MGP_BALBcJ_G0023900	protein coding gene	Chr17:56780131-56835282 (-)
C3H/HeJ	MGP_C3HHeJ_G0023664	protein coding gene	Chr17:58400116-58431504 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024346	protein coding gene	Chr17:60833219-60866762 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021792	protein coding gene	Chr17:53433478-53465812 (-)
CAST/EiJ	MGP_CASTEiJ_G0023146	protein coding gene	Chr17:58677044-58712680 (-)
CBA/J	MGP_CBAJ_G0023640	protein coding gene	Chr17:63218704-63253640 (-)
DBA/2J	MGP_DBA2J_G0023768	protein coding gene	Chr17:55659230-55690556 (-)
FVB/NJ	MGP_FVBNJ_G0023734	protein coding gene	Chr17:55224077-55257464 (-)
LP/J	MGP_LPJ_G0023850	protein coding gene	Chr17:59256834-59287884 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023762	protein coding gene	Chr17:62692022-62723865 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024390	protein coding gene	Chr17:58041423-58072684 (-)
PWK/PhJ	MGP_PWKPhJ_G0022892	protein coding gene	Chr17:55023850-55055716 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022703	protein coding gene	Chr17:54798768-54836650 (-)
WSB/EiJ	MGP_WSBEiJ_G0023212	protein coding gene	Chr17:58654007-58685366 (-)

Human Ortholog

ACSBG2, acyl-CoA synthetase bubblegum family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACSBG2, acyl-CoA synthetase bubblegum family member 2
Synonyms

BGR, BRGL, PRTD-NY3, PRTDNY3
Links

HGNC:24174

NCBI Gene ID: 81616

neXtProt AC: NX_Q5FVE4

UniProt: Q5FVE4
Chr Location

19p13.3; chr19:6135247-6193094 (+) GRCh38

MGI Vertebrate Homology

Acsbg2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACSBG2
Gene Tree

Acsbg2

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

57
Endonuclease-mediated

3
Gene trapped

50
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

137 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acsbg2

ZFIN acsbg2

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All Sequences

37
RefSeq

11
UniProt

1
CCDS

CCDS28916.1

Ensembl

ENSMUSG00000024207 (Evidence)
NCBI Gene

328845

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024207	Ensembl Gene Model \| MGI Sequence Detail	31345	C57BL/6J	± kb
transcript	ENSMUST00000043062	Ensembl \| MGI Sequence Detail	2609	Not Applicable
polypeptide	ENSMUSP00000042352	Ensembl \| MGI Sequence Detail	667	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003656 long-chain-fatty-acid--CoA ligase ACSBG2

(term hierarchy)
EC

6.2.1.15, 6.2.1.3
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain

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All nucleic 3

cDNA 3

Microarray probesets 3

Summaries

All 35

Gene Ontology 8

Phenotypes 13
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acsbg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148841	Chr17:57181421-57181460 (-)	6 bp
Tssr148840	Chr17:57181400-57181414 (-)	40 bp
Tssr148839	Chr17:57181395-57181398 (-)	50 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24