Cyb5r2 MGI Mouse Gene Detail - MGI:2444415

Symbol

Cyb5r2
Name

cytochrome b5 reductase 2
Synonyms

D630003K02Rik

Feature Type

protein coding gene
IDs

MGI:2444415
NCBI Gene: 320635
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:107347662-107357239 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 57.21 cM
Mapping Data

2 experiments

SNPs within 2kb

461 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444415	protein coding gene	Chr7:107347653-107357407 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032799	protein coding gene	Chr7:111089884-111099461 (-)
A/J	MGP_AJ_G0032780	protein coding gene	Chr7:108334437-108344014 (-)
AKR/J	MGP_AKRJ_G0032712	protein coding gene	Chr7:111056333-111065910 (-)
BALB/cJ	MGP_BALBcJ_G0032786	protein coding gene	Chr7:108032221-108041798 (-)
C3H/HeJ	MGP_C3HHeJ_G0032495	protein coding gene	Chr7:111076322-111085899 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033291	protein coding gene	Chr7:115674936-115684513 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030269	protein coding gene	Chr7:109982752-109992673 (-)
CAST/EiJ	MGP_CASTEiJ_G0031826	protein coding gene	Chr7:102682760-102692436 (-)
CBA/J	MGP_CBAJ_G0032470	protein coding gene	Chr7:119484552-119494129 (-)
DBA/2J	MGP_DBA2J_G0032621	protein coding gene	Chr7:106465242-106474819 (-)
FVB/NJ	MGP_FVBNJ_G0032573	protein coding gene	Chr7:106317998-106327575 (-)
LP/J	MGP_LPJ_G0032713	protein coding gene	Chr7:112687138-112696715 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032607	protein coding gene	Chr7:121092797-121102487 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033310	protein coding gene	Chr7:110118025-110128839 (-)
PWK/PhJ	MGP_PWKPhJ_G0031532	protein coding gene	Chr7:99337954-99347527 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031382	protein coding gene	Chr7:96706734-96716464 (-)
WSB/EiJ	MGP_WSBEiJ_G0031941	protein coding gene	Chr7:110869333-110879073 (-)

Human Ortholog

CYB5R2, cytochrome b5 reductase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYB5R2, cytochrome b5 reductase 2
Synonyms

B5R.2
Links

HGNC:24376

NCBI Gene ID: 51700

neXtProt AC: NX_Q6BCY4

UniProt: Q6BCY4
Chr Location

11p15.4; chr11:7665095-7677222 (-) GRCh38

MGI Vertebrate Homology

Cyb5r2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYB5R2
Gene Tree

Cyb5r2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
16 phenotype references

All Mutations and Alleles

4
Chemically induced (other)

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Cyb5r2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

13 strains or lines available

Mice homozygous for a targeted allele exhibit normal cATR-induced effects on mitochondria membrane potential during respiratory arrest by rotenone or anoxia.

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All GO Annotations

10
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cyb5r2

ZFIN cyb5r2

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All Sequences

48
RefSeq

16
UniProt

1
CCDS

CCDS57579.1, CCDS85373.1

Ensembl

ENSMUSG00000048065 (Evidence)
NCBI Gene

320635

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048065	Ensembl Gene Model \| MGI Sequence Detail	9578	C57BL/6J	± kb
transcript	ENSMUST00000052438	Ensembl \| MGI Sequence Detail	2772	Not Applicable
polypeptide	ENSMUSP00000050061	Ensembl \| MGI Sequence Detail	292	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006081 NADH-cytochrome b5 reductase 2

(term hierarchy)
EC

1.6.2.2
InterPro Domains

IPR017927 FAD-binding domain, ferredoxin reductase-type

IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase

IPR008333 Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain

IPR001834 NADH:cytochrome b5 reductase-like

IPR001433 Oxidoreductase FAD/NAD(P)-binding

IPR017938 Riboflavin synthase-like beta-barrel

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All nucleic 8

cDNA 8

Microarray probesets 2

Summaries

All 40

Gene Ontology 8

Phenotypes 16
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cyb5r2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr74163	Chr7:107357200-107357217 (-)	30 bp
Tssr74162	Chr7:107357104-107357142 (-)	116 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24