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Sting1 Gene Detail
Summary
  • Symbol
    Sting1
  • Name
    stimulator of interferon response cGAMP interactor 1
  • Synonyms
    2610307O08Rik, ERIS, MPYS, Sting, Tmem173
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919762
    NCBI Gene: 72512
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35866732-35873607 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.23 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919762
 protein coding gene Chr18:35866731-35873607 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024270
 protein coding gene Chr18:34065100-34071974 (-)
A/J MGP_AJ_G0024236
 protein coding gene Chr18:32887525-32894401 (-)
AKR/J MGP_AKRJ_G0024204
 protein coding gene Chr18:33821674-33828550 (-)
BALB/cJ MGP_BALBcJ_G0024236
 protein coding gene Chr18:32932480-32939356 (-)
C3H/HeJ MGP_C3HHeJ_G0024003
 protein coding gene Chr18:33852529-33860028 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024677
 protein coding gene Chr18:35285057-35291933 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022117
 protein coding gene Chr18:32993047-32998907 (-)
CAST/EiJ MGP_CASTEiJ_G0023478
 protein coding gene Chr18:33830089-33837091 (-)
CBA/J MGP_CBAJ_G0023971
 protein coding gene Chr18:36312670-36319546 (-)
DBA/2J MGP_DBA2J_G0024103
 protein coding gene Chr18:32522037-32528903 (-)
FVB/NJ MGP_FVBNJ_G0024070
 protein coding gene Chr18:32211456-32219739 (-)
LP/J MGP_LPJ_G0024185
 protein coding gene Chr18:34118028-34124904 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024098
 protein coding gene Chr18:37531592-37538560 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024726
 protein coding gene Chr18:33654464-33661340 (-)
PWK/PhJ MGP_PWKPhJ_G0023222
 protein coding gene Chr18:32747702-32757546 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023029
 protein coding gene Chr18:33924214-33930613 (-)
WSB/EiJ MGP_WSBEiJ_G0023541
 protein coding gene Chr18:33585140-33592016 (-)



Homology
more
  • Human Ortholog
    STING1, stimulator of interferon response cGAMP interactor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STING1, stimulator of interferon response cGAMP interactor 1
  • Synonyms
    ERIS, hMITA, hSTING, MITA, MPYS, NET23, SAVI, STING, STING-beta, TMEM173
  • Links
    NCBI Gene ID: 340061
    neXtProt AC: NX_Q86WV6
    UniProt: Q86WV6

  • Chr Location
    5q31.2; chr5:139475533-139482935 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sting1 mouse models; 1 with human STING1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 6 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    410 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to viral infection and abnormal innate immunity. Mice homozygous for an ENU-induced allele exhibit altered response to bacterial and viral infection. Male mice homozygous for a null allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    114
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    6
  • cDNA Data
    44
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024349 Ensembl Gene Model | MGI Sequence Detail 6876 C57BL/6J ±  kb
    transcript ENSMUST00000237919 Ensembl | MGI Sequence Detail 2134 Not Applicable  
    polypeptide ENSMUSP00000157408 Ensembl | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 44
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:6368843
    References
    more
    • Summaries
      All 551
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 31
      Phenotypes 410
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:358460 Sun T, et al., Neutrophil extracellular traps induce barrier dysfunction in DSS-induced ulcerative colitis via the cGAS-STING pathway. Int Immunopharmacol. 2024 Dec 25;143(Pt 1):113358
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory