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Enpp7 Gene Detail
Summary
  • Symbol
    Enpp7
  • Name
    ectonucleotide pyrophosphatase/phosphodiesterase 7
  • Synonyms
    Alk-SMase, LOC238011
  • Feature Type
    protein coding gene
  • IDs
    MGI:3027917
    NCBI Gene: 238011
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:118879014-118884047 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3027917
 protein coding gene Chr11:118879007-118884047 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019471
 protein coding gene Chr11:123329283-123333920 (+)
A/J MGP_AJ_G0019439
 protein coding gene Chr11:117882465-117887118 (+)
AKR/J MGP_AKRJ_G0019409
 protein coding gene Chr11:121440572-121445209 (+)
BALB/cJ MGP_BALBcJ_G0019414
 protein coding gene Chr11:118243131-118247776 (+)
C3H/HeJ MGP_C3HHeJ_G0019220
 protein coding gene Chr11:121754202-121758847 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019863
 protein coding gene Chr11:127097997-127102638 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017488
 protein coding gene Chr11:114879866-114884443 (+)
CAST/EiJ MGP_CASTEiJ_G0018774
 protein coding gene Chr11:123192563-123229922 (+)
CBA/J MGP_CBAJ_G0019191
 protein coding gene Chr11:132030882-132035527 (+)
DBA/2J MGP_DBA2J_G0019303
 protein coding gene Chr11:117260588-117265233 (+)
FVB/NJ MGP_FVBNJ_G0019295
 protein coding gene Chr11:116917319-116921954 (+)
LP/J MGP_LPJ_G0019373
 protein coding gene Chr11:123652449-123657094 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019328
 protein coding gene Chr11:130999379-131004116 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019902
 protein coding gene Chr11:122110643-122115286 (+)
PWK/PhJ MGP_PWKPhJ_G0018540
 protein coding gene Chr11:118573499-118683659 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018332
 protein coding gene Chr11:121853018-121880855 (+)
WSB/EiJ MGP_WSBEiJ_G0018826
 protein coding gene Chr11:122072390-122077045 (+)



Homology
more
  • Human Ortholog
    ENPP7, ectonucleotide pyrophosphatase/phosphodiesterase 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENPP7, ectonucleotide pyrophosphatase/phosphodiesterase 7
  • Synonyms
    ALK-SMase, E-NPP 7, NPP-7, NPP7
  • Links
    NCBI Gene ID: 339221
    neXtProt AC: NX_Q6UWV6
    UniProt: Q6UWV6

  • Chr Location
    17q25.3; chr17:79730943-79742219 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit intestinal epithelium hypertrophy, decreased crypt and villi width, and impaired sphingomyelin digestion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046697 Ensembl Gene Model | MGI Sequence Detail 5034 C57BL/6J ±  kb
    transcript ENSMUST00000092373 Ensembl | MGI Sequence Detail 1370 Not Applicable  
    polypeptide ENSMUSP00000090027 Ensembl | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007091 ectonucleotide pyrophosphatase/phosphodiesterase family member 7
      (term hierarchy)
    • EC
      3.1.4.12
    • InterPro Domains
      IPR017850 Alkaline-phosphatase-like, core domain superfamily
      IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
    • GlyGen
      Q3TIW9 5 sites
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685100
    References
    more
    • Summaries
      All 26
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:85836 Duan RD, et al., Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. J Biol Chem. 2003 Oct 3;278(40):38528-36
    • Latest
      J:266041 Zhang P, et al., Deficiency of alkaline SMase enhances dextran sulfate sodium-induced colitis in mice with upregulation of autotaxin. J Lipid Res. 2018 Oct;59(10):1841-1850
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory