Plb1 MGI Mouse Gene Detail - MGI:1922406

Symbol

Plb1
Name

phospholipase B1
Synonyms

4632413E21Rik, 4930433E17Rik, 4930539A06Rik, MGC:40917

Feature Type

protein coding gene
IDs

MGI:1922406
NCBI Gene: 665270
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:32390035-32521700 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.33 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

3138 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922406	protein coding gene	Chr5:32390035-32523864 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029434	protein coding gene	Chr5:30303934-30451402 (+)
A/J	MGP_AJ_G0029400	protein coding gene	Chr5:29307204-29445912 (+)
AKR/J	MGP_AKRJ_G0029350	protein coding gene	Chr5:30473892-30616191 (+)
BALB/cJ	MGP_BALBcJ_G0029411	protein coding gene	Chr5:29833584-29974352 (+)
C3H/HeJ	MGP_C3HHeJ_G0029132	protein coding gene	Chr5:30487213-30627132 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029864	protein coding gene	Chr5:32105074-32249086 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027102	protein coding gene	Chr5:26969608-27108593 (+)
CAST/EiJ	MGP_CASTEiJ_G0028542	protein coding gene	Chr5:29576976-29716909 (+)
CBA/J	MGP_CBAJ_G0029100	protein coding gene	Chr5:32787628-32943345 (+)
DBA/2J	MGP_DBA2J_G0029249	protein coding gene	Chr5:29481458-29615295 (+)
FVB/NJ	MGP_FVBNJ_G0029207	protein coding gene	Chr5:28891454-29031205 (+)
LP/J	MGP_LPJ_G0029334	protein coding gene	Chr5:30738534-30887825 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029236	protein coding gene	Chr5:33605203-33743888 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029898	protein coding gene	Chr5:29975963-30112545 (+)
PWK/PhJ	MGP_PWKPhJ_G0028267	protein coding gene	Chr5:28637093-28778230 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028098	protein coding gene	Chr5:29448836-29593703 (+)
WSB/EiJ	MGP_WSBEiJ_G0028623	protein coding gene	Chr5:30059850-30204729 (+)

Human Ortholog

PLB1, phospholipase B1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLB1, phospholipase B1
Synonyms

PLB, PLB/LIP
Links

HGNC:30041

NCBI Gene ID: 151056

neXtProt AC: NX_Q6P1J6

UniProt: Q6P1J6
Chr Location

2p23.2; chr2:28457145-28644142 (+) GRCh38

MGI Vertebrate Homology

Plb1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLB1
Gene Tree

Plb1

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

2
Spontaneous

1
Genomic Mutations

6 involving Plb1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

34
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

5
cDNA Data

22
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plb1

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All Sequences

56
RefSeq

12
UniProt

2
CCDS

CCDS39060.1

Ensembl

ENSMUSG00000029134 (Evidence)
NCBI Gene

665270

			Length	Strain/Species	Flank
genomic	665270	NCBI Gene Model \| MGI Sequence Detail	131666	C57BL/6J	± kb
transcript	NM_001081407	RefSeq \| MGI Sequence Detail	4853	C57BL/6
polypeptide	Q3TTY0	UniProt \| EBI \| MGI Sequence Detail	1478	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012827 phospholipase B1, membrane-associated

(term hierarchy)
EC

3.1.1.3, 3.1.1.4, 3.1.1.5
InterPro Domains

IPR001087 GDSL lipase/esterase

IPR008265 Lipase, GDSL, active site

IPR035547 Phospholipase B

IPR038885 Phospholipase B1, membrane-associated

IPR036514 SGNH hydrolase superfamily
GlyGen

Q3TTY0 14 sites

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All nucleic 23

Genomic 1

cDNA 22

Microarray probesets 11

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MGI:1921214, MGI:1925511, MGI:2387632

Summaries

All 57

Developmental Gene Expression 1

Diseases 1

Gene Ontology 7

Phenotypes 28
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Plb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45766	Chr5:32390024-32390073 (+)	14 bp
Tssr45767	Chr5:32398513-32398528 (+)	8,486 bp
Tssr45768	Chr5:32404793-32404812 (+)	14,768 bp
Tssr45769	Chr5:32454972-32454974 (+)	64,938 bp
Tssr45770	Chr5:32510866-32510880 (+)	120,838 bp
Tssr45771	Chr5:32510934-32510966 (+)	120,915 bp
Tssr45772	Chr5:32510968-32510998 (+)	120,948 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24