Mbd6 MGI Mouse Gene Detail - MGI:106378 - methyl-CpG binding domain protein 6

Symbol

Mbd6
Name

methyl-CpG binding domain protein 6
Synonyms

D10Wsu93e

Feature Type

protein coding gene
IDs

MGI:106378
NCBI Gene: 110962
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr10:127117825-127124887 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 74.50 cM
Mapping Data

5 experiments

SNPs within 2kb

152 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106378	protein coding gene	Chr10:127117825-127126738 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017815	protein coding gene	Chr10:130872411-130879256 (-)
A/J	MGP_AJ_G0017790	protein coding gene	Chr10:125627315-125634377 (-)
AKR/J	MGP_AKRJ_G0017753	protein coding gene	Chr10:129341651-129350417 (-)
BALB/cJ	MGP_BALBcJ_G0017754	protein coding gene	Chr10:126038854-126046177 (-)
C3H/HeJ	MGP_C3HHeJ_G0017578	protein coding gene	Chr10:129494510-129501578 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018209	protein coding gene	Chr10:135307868-135314912 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015889	protein coding gene	Chr10:119636127-119643213 (-)
CAST/EiJ	MGP_CASTEiJ_G0017138	protein coding gene	Chr10:130151930-130160407 (-)
CBA/J	MGP_CBAJ_G0017547	protein coding gene	Chr10:140759643-140766711 (-)
DBA/2J	MGP_DBA2J_G0017653	protein coding gene	Chr10:124719790-124726849 (-)
FVB/NJ	MGP_FVBNJ_G0017648	protein coding gene	Chr10:123660200-123667461 (-)
LP/J	MGP_LPJ_G0017727	protein coding gene	Chr10:131441312-131449560 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017676	protein coding gene	Chr10:143463203-143470262 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018249	protein coding gene	Chr10:129408056-129415115 (-)
PWK/PhJ	MGP_PWKPhJ_G0016923	protein coding gene	Chr10:124922870-124929993 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016715	protein coding gene	Chr10:128443896-128454095 (-)
WSB/EiJ	MGP_WSBEiJ_G0017199	protein coding gene	Chr10:129637058-129645315 (-)

Human Ortholog

MBD6, methyl-CpG binding domain protein 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MBD6, methyl-CpG binding domain protein 6
Links

HGNC:20445

NCBI Gene ID: 114785

neXtProt AC: NX_Q96DN6

UniProt: Q96DN6
Chr Location

chr12:57520710-57531545 (+) GRCh38

MGI Vertebrate Homology

Mbd6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MBD6
Gene Tree

Mbd6

Diseases

1 with human MBD6 associations

				Human Disease	Mouse Models
				autism spectrum disorder IDs autism spectrum disorder DOID:0060041 MESH:D000067877

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Gene trapped

5
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

833
Tissues

50
cDNA Data

14
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mbd6

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All Sequences

87
RefSeq

26
UniProt

13
CCDS

CCDS24235.1, CCDS83762.1

Ensembl

ENSMUSG00000025409 (Evidence)
NCBI Gene

110962

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025409	Ensembl Gene Model \| MGI Sequence Detail	7063	C57BL/6J	± kb
transcript	ENSMUST00000026476	Ensembl \| MGI Sequence Detail	4165	Not Applicable
polypeptide	ENSMUSP00000026476	Ensembl \| MGI Sequence Detail	1005	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000031534 methyl-CpG-binding domain protein 6

(term hierarchy)
InterPro Domains

IPR016177 DNA-binding domain superfamily

IPR001739 Methyl-CpG DNA binding

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 3

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MGD-MRK-34071

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 12
Earliest

J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mbd6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99763	Chr10:127124925-127124936 (-)	-44 bp
Tssr99762	Chr10:127124868-127124904 (-)	1 bp
Tssr99761	Chr10:127124834-127124866 (-)	37 bp
Tssr99760	Chr10:127124720-127124787 (-)	133 bp
Tssr99759	Chr10:127124688-127124715 (-)	185 bp
Tssr99758	Chr10:127124628-127124643 (-)	251 bp
Tssr99757	Chr10:127124479-127124502 (-)	396 bp
Tssr99756	Chr10:127124302-127124329 (-)	571 bp
Tssr99755	Chr10:127124284-127124299 (-)	595 bp
Tssr99754	Chr10:127122293-127122300 (-)	2,590 bp
Tssr99753	Chr10:127122120-127122132 (-)	2,761 bp
Tssr99752	Chr10:127118433-127118454 (-)	6,443 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24