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Rufy4 Gene Detail
Summary
  • Symbol
    Rufy4
  • Name
    RUN and FYVE domain containing 4
  • Synonyms
    F930048N03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3588214
    NCBI Gene: 435626
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74164700-74187382 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    835 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588214
 protein coding gene Chr1:74163768-74187389 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016140
 protein coding gene Chr1:74707521-74732058 (+)
A/J MGP_AJ_G0016123
 protein coding gene Chr1:72091824-72114248 (+)
AKR/J MGP_AKRJ_G0016080
 protein coding gene Chr1:74096607-74120380 (+)
BALB/cJ MGP_BALBcJ_G0016078
 protein coding gene Chr1:72163015-72183013 (+)
C3H/HeJ MGP_C3HHeJ_G0015909
 protein coding gene Chr1:74421213-74447055 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016531
 protein coding gene Chr1:77612995-77638551 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014252
 protein coding gene Chr1:67671005-67693159 (+)
CAST/EiJ MGP_CASTEiJ_G0015493
 protein coding gene Chr1:73730380-73756783 (+)
CBA/J MGP_CBAJ_G0015882
 protein coding gene Chr1:80119980-80149904 (+)
DBA/2J MGP_DBA2J_G0015983
 protein coding gene Chr1:71423084-71447695 (+)
FVB/NJ MGP_FVBNJ_G0015986
 protein coding gene Chr1:70602408-70623300 (+)
LP/J MGP_LPJ_G0016055
 protein coding gene Chr1:75800954-75825243 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016006
 protein coding gene Chr1:83556773-83582169 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016578
 protein coding gene Chr1:74145400-74169355 (+)
PWK/PhJ MGP_PWKPhJ_G0015280
 protein coding gene Chr1:70864835-70889424 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015058
 protein coding gene Chr1:73514534-73537484 (+)
WSB/EiJ MGP_WSBEiJ_G0015555
 protein coding gene Chr1:73951085-73975279 (+)



Homology
more
  • Human Ortholog
    RUFY4, RUN and FYVE domain containing 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RUFY4, RUN and FYVE domain containing 4
  • Synonyms
    ZFYVE31
  • Links
    NCBI Gene ID: 285180
    neXtProt AC: NX_Q6ZNE9
    UniProt: Q6ZNE9

  • Chr Location
    2q35; chr2:218034934-218090652 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    5
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061815 Ensembl Gene Model | MGI Sequence Detail 22683 C57BL/6J ±  kb
transcript ENSMUST00000127134 Ensembl | MGI Sequence Detail 1841 Not Applicable  
polypeptide ENSMUSP00000115873 Ensembl | MGI Sequence Detail 563 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 5
    Primer pair 2

    Microarray probesets 1
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:354513 Kim M, et al., RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts. Bone Res. 2024 May 15;12(1):29
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory