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Esyt2 Gene Detail
Summary
  • Symbol
    Esyt2
  • Name
    extended synaptotagmin-like protein 2
  • Synonyms
    2310058N22Rik, 2410017M09Rik, 4921504I16Rik, D12Ertd551e, Fam62b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261845
    NCBI Gene: 52635
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:116244816-116354670 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, Syntenic
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2500 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261845
 protein coding gene Chr12:116242903-116354670 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020181
 protein coding gene Chr12:119143799-119235990 (+)
A/J MGP_AJ_G0020137
 protein coding gene Chr12:114792321-114885150 (+)
AKR/J MGP_AKRJ_G0020112
 protein coding gene Chr12:118273166-118375110 (+)
BALB/cJ MGP_BALBcJ_G0020120
 protein coding gene Chr12:115216207-115307064 (+)
C3H/HeJ MGP_C3HHeJ_G0019924
 protein coding gene Chr12:118536392-118631950 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020567
 protein coding gene Chr12:122901328-123004339 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018179
 protein coding gene Chr12:110491853-111300872 (+)
CAST/EiJ MGP_CASTEiJ_G0019464
 protein coding gene Chr12:112388627-112479746 (+)
CBA/J MGP_CBAJ_G0019891
 protein coding gene Chr12:127778039-127880377 (+)
DBA/2J MGP_DBA2J_G0020008
 protein coding gene Chr12:114153969-114247569 (+)
FVB/NJ MGP_FVBNJ_G0019993
 protein coding gene Chr12:112842621-112938615 (+)
LP/J MGP_LPJ_G0020082
 protein coding gene Chr12:119184153-119279355 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020029
 protein coding gene Chr12:131078693-131195550 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020596
 protein coding gene Chr12:117445186-117537106 (+)
PWK/PhJ MGP_PWKPhJ_G0019226
 protein coding gene Chr12:108907102-109002981 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019031
 protein coding gene Chr12:110376005-110478400 (+)
WSB/EiJ MGP_WSBEiJ_G0019522
 protein coding gene Chr12:118396135-118490564 (+)



Homology
more
  • Human Ortholog
    ESYT2, extended synaptotagmin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ESYT2, extended synaptotagmin 2
  • Synonyms
    CHR2SYT, E-Syt2, FAM62B
  • Links
    NCBI Gene ID: 57488
    neXtProt AC: NX_A0FGR8
    UniProt: A0FGR8

  • Chr Location
    7q36.3; chr7:158730995-158830253 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice are viable and fertile without overt morphological defects except reduced FGF-stimulated mouse embryonic fibroblast migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    33
  • cDNA Data
    155
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021171 Ensembl Gene Model | MGI Sequence Detail 109855 C57BL/6J ±  kb
    transcript ENSMUST00000100986 Ensembl | MGI Sequence Detail 5560 Not Applicable  
    polypeptide ENSMUSP00000098548 Ensembl | MGI Sequence Detail 845 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 159
      cDNA 155
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919171, MGI:1919208, MGI:1921297
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory