Slc38a5 MGI Mouse Gene Detail - MGI:2148066 - solute carrier family 38, member 5

Symbol

Slc38a5
Name

solute carrier family 38, member 5
Synonyms

C81234, JM24, SN2

Feature Type

protein coding gene
IDs

MGI:2148066
NCBI Gene: 209837
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

ChrX:8137620-8146418 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 3.74 cM
Mapping Data

1 experiment

SNPs within 2kb

210 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2148066	protein coding gene	ChrX:8137372-8146418 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035546	protein coding gene	ChrX:2928560-2938725 (+)
A/J	MGP_AJ_G0035523	protein coding gene	ChrX:2909487-2918255 (+)
AKR/J	MGP_AKRJ_G0035456	protein coding gene	ChrX:3025508-3034537 (+)
BALB/cJ	MGP_BALBcJ_G0035520	protein coding gene	ChrX:2894108-2903150 (+)
C3H/HeJ	MGP_C3HHeJ_G0035228	protein coding gene	ChrX:2987050-2996149 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036044	protein coding gene	ChrX:3036831-3045753 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032919	protein coding gene	ChrX:2420735-2429662 (+)
CAST/EiJ	MGP_CASTEiJ_G0034529	protein coding gene	ChrX:2866768-2877741 (+)
CBA/J	MGP_CBAJ_G0035198	protein coding gene	ChrX:3184159-3196518 (+)
DBA/2J	MGP_DBA2J_G0035355	protein coding gene	ChrX:2879484-2888396 (+)
FVB/NJ	MGP_FVBNJ_G0035302	protein coding gene	ChrX:2856515-2865444 (+)
LP/J	MGP_LPJ_G0035432	protein coding gene	ChrX:2950579-2959574 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035342	protein coding gene	ChrX:3125955-3136223 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036062	protein coding gene	ChrX:2908727-2917969 (+)
PWK/PhJ	MGP_PWKPhJ_G0034229	protein coding gene	ChrX:2823476-2832575 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034068	protein coding gene	ChrX:2888979-2900057 (+)
WSB/EiJ	MGP_WSBEiJ_G0034652	protein coding gene	ChrX:2912999-2921882 (+)

Human Ortholog

SLC38A5, solute carrier family 38 member 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC38A5, solute carrier family 38 member 5
Synonyms

JM24, pp7194, SN2, SNAT5
Links

HGNC:18070

NCBI Gene ID: 92745

neXtProt AC: NX_Q8WUX1

UniProt: Q8WUX1
Chr Location

Xp11.23; chrX:48458537-48470260 (-) GRCh38

MGI Vertebrate Homology

Slc38a5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC38A5
Gene Tree

Slc38a5

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
7 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

5 strains or lines available

The gene product plays a role in mediating amino-acid-stimulated pancreatic alpha cell proliferation. Under glucagon receptor (Gcgr) inhibition conditions, homozygous KO reduces alpha cell hyperplasia and causes hypoglycemia and increased plasma glucagon and amino acid levels.

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All GO Annotations

63
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

869
Tissues

46
cDNA Data

22
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc38a5

ZFIN slc38a5a, slc38a5b

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All Sequences

43
RefSeq

2
UniProt

2
CCDS

CCDS52990.1

Ensembl

ENSMUSG00000031170 (Evidence)
NCBI Gene

209837

			Length	Strain/Species	Flank
genomic	209837	NCBI Gene Model \| MGI Sequence Detail	8799	C57BL/6J	± kb
transcript	NM_172479	RefSeq \| MGI Sequence Detail	1878	C57BL/6
polypeptide	Q3U1J0	UniProt \| EBI \| MGI Sequence Detail	479	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015122 sodium-coupled neutral amino acid transporter 5

(term hierarchy)
InterPro Domains

IPR013057 Amino acid transporter, transmembrane domain
GlyGen

Q3U1J0 1 site

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All nucleic 26

cDNA 22

Primer pair 4

Microarray probesets 3

Summaries

All 48

Developmental Gene Expression 10

Gene Ontology 8

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:351647 Zhu L, et al., SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification. Cell Rep. 2023 Aug 1;42(8):112910

TSS for Slc38a5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160492	ChrX:8137407-8137418 (+)	-207 bp
Tssr160493	ChrX:8137624-8137692 (+)	38 bp
Tssr160494	ChrX:8137712-8137723 (+)	98 bp
Tssr160495	ChrX:8137807-8137817 (+)	192 bp
Tssr160496	ChrX:8137919-8138029 (+)	354 bp
Tssr160497	ChrX:8138458-8138469 (+)	844 bp
Tssr160498	ChrX:8138483-8138503 (+)	873 bp
Tssr160499	ChrX:8138512-8138543 (+)	908 bp
Tssr160500	ChrX:8142371-8142383 (+)	4,757 bp
Tssr160501	ChrX:8142817-8142843 (+)	5,210 bp
Tssr160502	ChrX:8143010-8143018 (+)	5,394 bp
Tssr160503	ChrX:8143919-8143939 (+)	6,309 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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