Dennd1b MGI Mouse Gene Detail - MGI:2447812

Symbol

Dennd1b
Name

DENN domain containing 1B
Synonyms

4632404N19Rik, 4930467M19Rik, 6820401H01Rik, F730008N07Rik

Feature Type

protein coding gene
IDs

MGI:2447812
NCBI Gene: 329260
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:138891447-139103781 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 60.84 cM
Mapping Data

3 experiments

SNPs within 2kb

4249 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447812	protein coding gene	Chr1:138891173-139106698 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016550	protein coding gene	Chr1:143004022-143229555 (+)
A/J	MGP_AJ_G0016533	protein coding gene	Chr1:137449110-137663246 (+)
AKR/J	MGP_AKRJ_G0016498	protein coding gene	Chr1:141602778-141820194 (+)
BALB/cJ	MGP_BALBcJ_G0016493	protein coding gene	Chr1:137805117-138018573 (+)
C3H/HeJ	MGP_C3HHeJ_G0016319	protein coding gene	Chr1:141694820-141906848 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016954	protein coding gene	Chr1:148018825-148257734 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014665	protein coding gene	Chr1:130513880-130726628 (+)
CAST/EiJ	MGP_CASTEiJ_G0015899	protein coding gene	Chr1:140846535-141074779 (+)
CBA/J	MGP_CBAJ_G0016292	protein coding gene	Chr1:153126572-153359652 (+)
DBA/2J	MGP_DBA2J_G0016398	protein coding gene	Chr1:136459035-136674147 (+)
FVB/NJ	MGP_FVBNJ_G0016397	protein coding gene	Chr1:135093262-135301703 (+)
LP/J	MGP_LPJ_G0016469	protein coding gene	Chr1:144105604-144327093 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016422	protein coding gene	Chr1:158789351-159021766 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016990	protein coding gene	Chr1:141380003-141613053 (+)
PWK/PhJ	MGP_PWKPhJ_G0015685	protein coding gene	Chr1:135532724-135742700 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015472	protein coding gene	Chr1:140336478-140563662 (+)
WSB/EiJ	MGP_WSBEiJ_G0015962	protein coding gene	Chr1:141394615-141617724 (+)

Human Ortholog

DENND1B, DENN domain containing 1B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DENND1B, DENN domain containing 1B
Synonyms

C1ORF18, C1orf218, FAM31B
Links

HGNC:28404

NCBI Gene ID: 163486

neXtProt AC: NX_Q6P3S1

UniProt: Q6P3S1
Chr Location

1q31.3; chr1:197504748-197782150 (-) GRCh38

MGI Vertebrate Homology

Dennd1b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DENND1B
Gene Tree

Dennd1b

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Dennd1b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous KO results in enhanced allergic responses to aerosolized antigen challenges caused by delayed TCR down-modulation following receptor activation in T helper 2 cells.

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All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

13

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN dennd1b

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All Sequences

80
RefSeq

26
UniProt

4
CCDS

CCDS15335.1, CCDS35728.1, CCDS48384.1

Ensembl

ENSMUSG00000056268 (Evidence)
NCBI Gene

329260

			Length	Strain/Species	Flank
genomic	329260	NCBI Gene Model \| MGI Sequence Detail	212335	C57BL/6J	± kb
transcript	NM_001166501	RefSeq \| MGI Sequence Detail	8206	C57BL/6
polypeptide	Q3U1T9	UniProt \| EBI \| MGI Sequence Detail	766	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031602 DENN domain-containing protein 1B

(term hierarchy)
InterPro Domains

IPR001194 cDENN domain

IPR005112 dDENN domain

IPR040032 DENN domain-containing protein 1A/1B/1C

IPR043153 DENN domain, C-terminal lobe

IPR037516 Tripartite DENN domain

IPR005113 uDENN domain

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All nucleic 14

cDNA 14

Microarray probesets 5

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MGI:1922993, MGI:1924310, MGI:2443969, MGI:2670998

Summaries

All 40

Gene Ontology 7

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dennd1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9165	Chr1:138891155-138891210 (+)	-264 bp
Tssr9166	Chr1:138891367-138891422 (+)	-52 bp
Tssr9167	Chr1:138891455-138891546 (+)	54 bp
Tssr9169	Chr1:138984496-138984501 (+)	93,052 bp
Tssr9170	Chr1:139099798-139099810 (+)	208,357 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24