Ahrr MGI Mouse Gene Detail - MGI:1333776 - aryl-hydrocarbon receptor repressor

Symbol

Ahrr
Name

aryl-hydrocarbon receptor repressor

Feature Type

protein coding gene
IDs

MGI:1333776
NCBI Gene: 11624
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:74359237-74440450 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 40.15 cM, cytoband C2
Mapping Data

2 experiments

SNPs within 2kb

2320 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333776	protein coding gene	Chr13:74359237-74440450 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020761	protein coding gene	Chr13:74711956-74783431 (-)
A/J	MGP_AJ_G0020717	protein coding gene	Chr13:72042158-72111085 (-)
AKR/J	MGP_AKRJ_G0020691	protein coding gene	Chr13:74295577-74376644 (-)
BALB/cJ	MGP_BALBcJ_G0020714	protein coding gene	Chr13:72535445-72604537 (-)
C3H/HeJ	MGP_C3HHeJ_G0020508	protein coding gene	Chr13:73981025-74065743 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021151	protein coding gene	Chr13:77193735-77265020 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018718	protein coding gene	Chr13:68866292-68948641 (-)
CAST/EiJ	MGP_CASTEiJ_G0020025	protein coding gene	Chr13:73065496-73148135 (-)
CBA/J	MGP_CBAJ_G0020467	protein coding gene	Chr13:80059643-80133798 (-)
DBA/2J	MGP_DBA2J_G0020592	protein coding gene	Chr13:71858041-71928135 (-)
FVB/NJ	MGP_FVBNJ_G0020572	protein coding gene	Chr13:70883522-70951173 (-)
LP/J	MGP_LPJ_G0020665	protein coding gene	Chr13:74944744-75016470 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020600	protein coding gene	Chr13:78465880-78541811 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021190	protein coding gene	Chr13:73614002-73685918 (-)
PWK/PhJ	MGP_PWKPhJ_G0019779	protein coding gene	Chr13:70603747-70673580 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019602	protein coding gene	Chr13:70104429-70178504 (-)
WSB/EiJ	MGP_WSBEiJ_G0020083	protein coding gene	Chr13:74171743-74252148 (-)

Human Ortholog

AHRR, aryl hydrocarbon receptor repressor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AHRR, aryl hydrocarbon receptor repressor
Synonyms

AHH, AHHR, bHLHe77
Links

HGNC:346

NCBI Gene ID: 57491

neXtProt AC: NX_A9YTQ3

UniProt: A9YTQ3
Chr Location

5p15.33; chr5:321714-438291 (+) GRCh38

MGI Vertebrate Homology

Ahrr stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: AHRR
Gene Tree

Ahrr

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

1 involving Ahrr
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased susceptibility to chemically induced tumors.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

815
Tissues

109
cDNA Data

13
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ahrr

ZFIN ahrra, ahrrb

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All Sequences

52
RefSeq

10
UniProt

4
CCDS

CCDS26641.1, CCDS84037.1

Ensembl

ENSMUSG00000021575 (Evidence)
NCBI Gene

11624

			Length	Strain/Species	Flank
genomic	11624	NCBI Gene Model \| MGI Sequence Detail	81214	C57BL/6J	± kb
transcript	NM_009644	RefSeq \| MGI Sequence Detail	4754	C57BL/6
polypeptide	Q3U1U7	UniProt \| EBI \| MGI Sequence Detail	701	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003859 aryl hydrocarbon receptor repressor

(term hierarchy)
InterPro Domains

IPR039091 Aryl hydrocarbon receptor/Aryl hydrocarbon receptor repressor

IPR039092 Aryl hydrocarbon receptor repressor, basic helix-loop-helix domain

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

IPR000014 PAS domain

IPR035965 PAS domain superfamily

IPR013767 PAS fold

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 3

Summaries

All 52

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 16
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:351326 Weighardt H, et al., The aryl hydrocarbon receptor (AHR) repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils. J Leukoc Biol. 2024 May 3;

TSS for Ahrr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123209	Chr13:74440402-74440462 (-)	18 bp
Tssr123208	Chr13:74368907-74368922 (-)	71,535 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24