Fam117b Gene Detail

Summary

• Symbol
  Fam117b
• Name
  family with sequence similarity 117, member B
• Synonyms
  2810425F24Rik, 6330416D14Rik, Als2cr13

• Feature Type
  protein coding gene
• IDs
  MGI:1920000
  NCBI Gene: 72750
• Alliance
  gene page
• Transcription Start Sites
  6 TSS

Location &
Maps

• Sequence Map
  Chr1:59952165-60024505 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 30.44 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  1188 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920000	protein coding gene	Chr1:59952165-60024507 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016071	protein coding gene	Chr1:59937070-60013359 (+)
A/J	MGP_AJ_G0016054	protein coding gene	Chr1:57826498-57899523 (+)
AKR/J	MGP_AKRJ_G0016010	protein coding gene	Chr1:59454493-59526248 (+)
BALB/cJ	MGP_BALBcJ_G0016009	protein coding gene	Chr1:57851959-57927636 (+)
C3H/HeJ	MGP_C3HHeJ_G0015841	protein coding gene	Chr1:59699284-59776501 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016462	protein coding gene	Chr1:62281939-62352512 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014183	protein coding gene	Chr1:54033402-54104022 (+)
CAST/EiJ	MGP_CASTEiJ_G0015423	protein coding gene	Chr1:58881842-58960725 (+)
CBA/J	MGP_CBAJ_G0015813	protein coding gene	Chr1:64217180-64294690 (+)
DBA/2J	MGP_DBA2J_G0015914	protein coding gene	Chr1:57253245-57324057 (+)
FVB/NJ	MGP_FVBNJ_G0015916	protein coding gene	Chr1:56553908-56625807 (+)
LP/J	MGP_LPJ_G0015986	protein coding gene	Chr1:60821651-60897073 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015936	protein coding gene	Chr1:67137172-67212927 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016509	protein coding gene	Chr1:59356861-59430552 (+)
PWK/PhJ	MGP_PWKPhJ_G0015210	protein coding gene	Chr1:56597741-56674586 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014990	protein coding gene	Chr1:58897491-58964921 (+)
WSB/EiJ	MGP_WSBEiJ_G0015486	protein coding gene	Chr1:59063384-59139244 (+)

Homology

• Human Ortholog
  FAM117B, family with sequence similarity 117 member B

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FAM117B, family with sequence similarity 117 member B
  
• Synonyms
  ALS2CR13
• Links
  HGNC:14440

  NCBI Gene ID: 150864

  neXtProt AC: NX_Q6P1L5

  UniProt: Q6P1L5

  
  
• Chr Location
  2q33.2

---

• MGI Vertebrate Homology
  Fam117b stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: FAM117B
• Gene Tree
  Fam117b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 1 allele in 1 genetic background
  11 phenotype references
  

• All Mutations and Alleles
  21
• Chemically induced (other)
  1
• Gene trapped
  17
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  2 involving Fam117b
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  30 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  708
• Tissues
  2
• cDNA Data
  92
• Literature Summary
  1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase fam117b

Sequences &
Gene Models

• All Sequences
  42
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS14986.1

• Ensembl
  ENSMUSG00000041040 (Evidence)
• NCBI Gene
  72750

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000041040	Ensembl Gene Model | MGI Sequence Detail	72341	C57BL/6J
transcript	ENSMUST00000036540	Ensembl | MGI Sequence Detail	5532	Not Applicable
polypeptide	ENSMUSP00000041671	Ensembl | MGI Sequence Detail	584	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000029455 protein FAM117B
  (term hierarchy)
• InterPro Domains
  IPR026642 Glucocorticoid-induced transcript 1/FAM117
• GlyGen
  Q3U3E2 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

Molecular
Reagents

• All nucleic 92

  cDNA 92

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:1917984

References

• Summaries
  All 33

  Developmental Gene Expression 1

  Phenotypes 11
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fam117b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6911	Chr1:59952131-59952186 (+)	-6 bp
Tssr6912	Chr1:59952212-59952223 (+)	53 bp
Tssr6913	Chr1:59952235-59952251 (+)	78 bp
Tssr6914	Chr1:59952642-59952695 (+)	504 bp
Tssr6915	Chr1:59998350-59998354 (+)	46,187 bp
Tssr6916	Chr1:60017121-60017123 (+)	64,957 bp