Vwce MGI Mouse Gene Detail - MGI:1919018 - von Willebrand factor C and EGF domains

Symbol

Vwce
Name

von Willebrand factor C and EGF domains
Synonyms

1300015B04Rik

Feature Type

protein coding gene
IDs

MGI:1919018
NCBI Gene: 71768
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:10611582-10643577 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 6.87 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

1009 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919018	protein coding gene	Chr19:10611577-10643577 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024853	protein coding gene	Chr19:7985823-8021661 (+)
A/J	MGP_AJ_G0024821	protein coding gene	Chr19:7445757-7480565 (+)
AKR/J	MGP_AKRJ_G0024796	protein coding gene	Chr19:7741841-7774873 (+)
BALB/cJ	MGP_BALBcJ_G0024821	protein coding gene	Chr19:7488387-7521960 (+)
C3H/HeJ	MGP_C3HHeJ_G0024587	protein coding gene	Chr19:7621472-7665464 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025269	protein coding gene	Chr19:8344351-8378682 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022696	protein coding gene	Chr19:7865459-7897791 (+)
CAST/EiJ	MGP_CASTEiJ_G0024060	protein coding gene	Chr19:7276967-7308362 (+)
CBA/J	MGP_CBAJ_G0024561	protein coding gene	Chr19:8387958-8427174 (+)
DBA/2J	MGP_DBA2J_G0024688	protein coding gene	Chr19:7455413-7487231 (+)
FVB/NJ	MGP_FVBNJ_G0024655	protein coding gene	Chr19:7500168-7531310 (+)
LP/J	MGP_LPJ_G0024775	protein coding gene	Chr19:7949136-7981379 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024682	protein coding gene	Chr19:8293402-8328297 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025317	protein coding gene	Chr19:7756207-7787985 (+)
PWK/PhJ	MGP_PWKPhJ_G0023805	protein coding gene	Chr19:6898154-6930696 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023610	protein coding gene	Chr19:6936977-6967392 (+)
WSB/EiJ	MGP_WSBEiJ_G0024122	protein coding gene	Chr19:7645803-7681467 (+)

Human Ortholog

VWCE, von Willebrand factor C and EGF domains

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VWCE, von Willebrand factor C and EGF domains
Synonyms

URG11, VWC1
Links

HGNC:26487

NCBI Gene ID: 220001

neXtProt AC: NX_Q96DN2

UniProt: Q96DN2
Chr Location

11q12.2; chr11:61258286-61295316 (-) GRCh38

MGI Vertebrate Homology

Vwce stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: VWCE
Gene Tree

Vwce

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

7
cDNA Data

13
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vwce

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All Sequences

47
RefSeq

12
UniProt

3
CCDS

CCDS50390.1

Ensembl

ENSMUSG00000043789 (Evidence)
NCBI Gene

71768

			Length	Strain/Species	Flank
genomic	71768	NCBI Gene Model \| MGI Sequence Detail	31996	C57BL/6J	± kb
transcript	NM_027913	RefSeq \| MGI Sequence Detail	4543	C57BL/6
polypeptide	Q3U515	UniProt \| EBI \| MGI Sequence Detail	929	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017363 von Willebrand factor C and EGF domain-containing protein

(term hierarchy)
InterPro Domains

IPR026823 Complement Clr-like EGF domain

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR052080 von Willebrand factor C/EGF & Fibrillin

IPR001007 VWFC domain
GlyGen

Q3U515 3 sites

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All nucleic 13

cDNA 13

Microarray probesets 2

Summaries

All 34

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vwce:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155079	Chr19:10611587-10611609 (+)	16 bp
Tssr155080	Chr19:10611664-10611676 (+)	88 bp
Tssr155081	Chr19:10611677-10611688 (+)	101 bp
Tssr155082	Chr19:10625590-10625597 (+)	14,012 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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