Parp8 MGI Mouse Gene Detail - MGI:1098713 - poly (ADP-ribose) polymerase family, member 8

Symbol

Parp8
Name

poly (ADP-ribose) polymerase family, member 8
Synonyms

2810430O08Rik, D13Ertd275e

Feature Type

protein coding gene
IDs

MGI:1098713
NCBI Gene: 52552
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr13:116991356-117162073 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 65.32 cM
Mapping Data

2 experiments

SNPs within 2kb

5825 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098713	protein coding gene	Chr13:116987378-117162549 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020962	protein coding gene	Chr13:119763331-119939766 (-)
A/J	MGP_AJ_G0020912	protein coding gene	Chr13:114864379-115047250 (-)
AKR/J	MGP_AKRJ_G0020887	protein coding gene	Chr13:118288086-118470116 (-)
BALB/cJ	MGP_BALBcJ_G0020912	protein coding gene	Chr13:115576374-115760325 (-)
C3H/HeJ	MGP_C3HHeJ_G0020701	protein coding gene	Chr13:118144538-118320559 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021348	protein coding gene	Chr13:123183337-123368582 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018917	protein coding gene	Chr13:110045728-110222250 (-)
CAST/EiJ	MGP_CASTEiJ_G0020220	protein coding gene	Chr13:117908320-118099500 (-)
CBA/J	MGP_CBAJ_G0020663	protein coding gene	Chr13:127965939-128156263 (-)
DBA/2J	MGP_DBA2J_G0020786	protein coding gene	Chr13:114532985-114707881 (-)
FVB/NJ	MGP_FVBNJ_G0020770	protein coding gene	Chr13:113187847-113358553 (-)
LP/J	MGP_LPJ_G0020862	protein coding gene	Chr13:119724317-119899806 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020798	protein coding gene	Chr13:128336270-128517924 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021384	protein coding gene	Chr13:117781653-117952154 (-)
PWK/PhJ	MGP_PWKPhJ_G0019973	protein coding gene	Chr13:113389644-113566750 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019795	protein coding gene	Chr13:114124840-114303632 (-)
WSB/EiJ	MGP_WSBEiJ_G0020278	protein coding gene	Chr13:118450981-118627139 (-)

Human Ortholog

PARP8, poly(ADP-ribose) polymerase family member 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARP8, poly(ADP-ribose) polymerase family member 8
Synonyms

ARTD16, pART16
Links

HGNC:26124

NCBI Gene ID: 79668

neXtProt AC: NX_Q8N3A8

UniProt: Q8N3A8
Chr Location

5q11.1; chr5:50665899-50846519 (+) GRCh38

MGI Vertebrate Homology

Parp8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PARP8
Gene Tree

Parp8

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1041
Tissues

73
cDNA Data

18
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase parp8

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All Sequences

80
RefSeq

20
UniProt

8
CCDS

CCDS36790.2

Ensembl

ENSMUSG00000021725 (Evidence)
NCBI Gene

52552

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021725	Ensembl Gene Model \| MGI Sequence Detail	170718	C57BL/6J	± kb
transcript	ENSMUST00000022239	Ensembl \| MGI Sequence Detail	3098	Not Applicable
polypeptide	ENSMUSP00000022239	Ensembl \| MGI Sequence Detail	891	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000012300 protein mono-ADP-ribosyltransferase PARP8

(term hierarchy)
EC

2.4.2.-
InterPro Domains

IPR051838 Intracellular mono-ADP-ribosyltransferase ARTD/PARP

IPR012317 Poly(ADP-ribose) polymerase, catalytic domain

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All nucleic 20

cDNA 18

Primer pair 2

Microarray probesets 3

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MGI:1917198

Summaries

All 38

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Parp8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124177	Chr13:117162468-117162499 (-)	-411 bp
Tssr124176	Chr13:117162370-117162390 (-)	-307 bp
Tssr124175	Chr13:117162082-117162093 (-)	-15 bp
Tssr124174	Chr13:117162041-117162077 (-)	14 bp
Tssr124173	Chr13:117161921-117161980 (-)	122 bp
Tssr124172	Chr13:117161883-117161900 (-)	181 bp
Tssr124171	Chr13:117161105-117161106 (-)	967 bp
Tssr124170	Chr13:117160676-117160708 (-)	1,381 bp
Tssr124169	Chr13:117151338-117151345 (-)	10,731 bp
Tssr124168	Chr13:117151297-117151312 (-)	10,768 bp
Tssr124167	Chr13:117105240-117105242 (-)	56,832 bp
Tssr124166	Chr13:117060458-117060475 (-)	101,606 bp
Tssr124165	Chr13:117025526-117025539 (-)	136,540 bp
Tssr124164	Chr13:117012906-117012920 (-)	149,160 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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