About   Help   FAQ
Pde4c Gene Detail
Summary
  • Symbol
    Pde4c
  • Name
    phosphodiesterase 4C, cAMP specific
  • Synonyms
    Dpde1, dunce, E130301F19Rik, MGC:31320
  • Feature Type
    protein coding gene
  • IDs
    MGI:99556
    NCBI Gene: 110385
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:71176485-71203835 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM, cytoband B3-C1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    762 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99556
 protein coding gene Chr8:71176369-71203835 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033722
 protein coding gene Chr8:71014603-71050451 (+)
A/J MGP_AJ_G0033705
 protein coding gene Chr8:68128329-68155848 (+)
AKR/J MGP_AKRJ_G0033630
 protein coding gene Chr8:70076983-70111951 (+)
BALB/cJ MGP_BALBcJ_G0033701
 protein coding gene Chr8:68361682-68391958 (+)
C3H/HeJ MGP_C3HHeJ_G0033411
 protein coding gene Chr8:70716598-70756442 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034218
 protein coding gene Chr8:73701816-73730964 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031162
 protein coding gene Chr8:62942628-62973531 (+)
CAST/EiJ MGP_CASTEiJ_G0032736
 protein coding gene Chr8:70198699-70229944 (+)
CBA/J MGP_CBAJ_G0033389
 protein coding gene Chr8:76352918-76393442 (+)
DBA/2J MGP_DBA2J_G0033543
 protein coding gene Chr8:67842452-67873848 (+)
FVB/NJ MGP_FVBNJ_G0033484
 protein coding gene Chr8:66972795-67010429 (+)
LP/J MGP_LPJ_G0033630
 protein coding gene Chr8:71039780-71071318 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033527
 protein coding gene Chr8:78995113-79023673 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034236
 protein coding gene Chr8:70254739-70288458 (+)
PWK/PhJ MGP_PWKPhJ_G0032444
 protein coding gene Chr8:67143204-67171826 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032280
 protein coding gene Chr8:69222807-69256403 (+)
WSB/EiJ MGP_WSBEiJ_G0032851
 protein coding gene Chr8:70625629-70657264 (+)



Homology
more
  • Human Ortholog
    PDE4C, phosphodiesterase 4C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE4C, phosphodiesterase 4C
  • Synonyms
    DPDE1, PDE21
  • Links
    NCBI Gene ID: 5143
    neXtProt AC: NX_Q08493
    UniProt: Q08493

  • Chr Location
    19p13.11; chr19:18207961-18255419 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal righting response following treatment with RS25344.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    102
  • cDNA Data
    14
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 110385 NCBI Gene Model | MGI Sequence Detail 27351 C57BL/6J ±  kb
transcript NM_001310465 RefSeq | MGI Sequence Detail 3305 C57BL/6  
polypeptide Q3UEI1 UniProt | EBI | MGI Sequence Detail 686 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000012474 3',5'-cyclic-AMP phosphodiesterase 4C
    (term hierarchy)
  • EC
    3.1.4.-, 3.1.4.53
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR003607 HD/PDEase domain
    IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)
Molecular
Reagents
less
  • All nucleic 18
    Genomic 1
    cDNA 17

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-16334, MGI:3036271
References
more
  • Summaries
    All 48
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory