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Wdr19 Gene Detail
Summary
  • Symbol
    Wdr19
  • Name
    WD repeat domain 19
  • Synonyms
    C330027H04Rik, D330023L08Rik, DYF2, Ift144
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443231
    NCBI Gene: 213081
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:65357039-65417758 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 33.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1804 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443231
 protein coding gene Chr5:65357039-65417758 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029573
 protein coding gene Chr5:64821242-64888693 (+)
A/J MGP_AJ_G0029541
 protein coding gene Chr5:62419624-62480236 (+)
AKR/J MGP_AKRJ_G0029489
 protein coding gene Chr5:64394636-64468054 (+)
BALB/cJ MGP_BALBcJ_G0029550
 protein coding gene Chr5:63104713-63168383 (+)
C3H/HeJ MGP_C3HHeJ_G0029273
 protein coding gene Chr5:64739448-64805258 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030004
 protein coding gene Chr5:67505850-67573620 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027244
 protein coding gene Chr5:58482199-58542878 (+)
CAST/EiJ MGP_CASTEiJ_G0028681
 protein coding gene Chr5:63835662-63900194 (+)
CBA/J MGP_CBAJ_G0029242
 protein coding gene Chr5:69686850-69760374 (+)
DBA/2J MGP_DBA2J_G0029388
 protein coding gene Chr5:62435301-62515414 (+)
FVB/NJ MGP_FVBNJ_G0029348
 protein coding gene Chr5:61625200-61686378 (+)
LP/J MGP_LPJ_G0029473
 protein coding gene Chr5:65310878-65379631 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029376
 protein coding gene Chr5:72575282-72643595 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030037
 protein coding gene Chr5:64072358-64139131 (+)
PWK/PhJ MGP_PWKPhJ_G0028405
 protein coding gene Chr5:61411464-61474149 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028239
 protein coding gene Chr5:63380755-63449089 (+)
WSB/EiJ MGP_WSBEiJ_G0028761
 protein coding gene Chr5:64270741-64335993 (+)



Homology
more
  • Human Ortholog
    WDR19, WD repeat domain 19
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR19, WD repeat domain 19
  • Synonyms
    ATD5, CED4, CFAP66, DYF-2, FAP66, IFT144, NPHP13, ORF26, Oseg6, PWDMP, SPGF72, SRTD5
  • Links
    NCBI Gene ID: 57728
    neXtProt AC: NX_Q8NEZ3
    UniProt: Q8NEZ3

  • Chr Location
    4p14
Human Diseases
more
  • Diseases
    1 with Wdr19 mouse models; 7 with human WDR19 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 2 alleles in 1 genetic background
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E10.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    16
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    17
  • cDNA Data
    45
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 213081 NCBI Gene Model | MGI Sequence Detail 60720 C57BL/6J ±  kb
    transcript NM_001359879 RefSeq | MGI Sequence Detail 5276 C57BL/6  
    polypeptide Q3UGF1 UniProt | EBI | MGI Sequence Detail 1341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000032482 WD repeat-containing protein 19
      (term hierarchy)
    • InterPro Domains
      IPR024977 Anaphase-promoting complex subunit 4-like, WD40 domain
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR001680 WD40 repeat
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
      IPR039468 WDR19, WD40 repeat
      IPR040379 WD repeat-containing protein 19/dyf-2
    • GlyGen
      Q3UGF1 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 45
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1924484
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 16
      Phenotypes 23
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:306217 Lee H, et al., Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development. BMB Rep. 2020 Jul;53(7):367-372
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory