Tnrc6c MGI Mouse Gene Detail - MGI:2443265 - trinucleotide repeat containing 6C

Symbol

Tnrc6c
Name

trinucleotide repeat containing 6C
Synonyms

9930033H14Rik, mKIAA1582

Feature Type

protein coding gene
IDs

MGI:2443265
NCBI Gene: 217351
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:117545115-117654265 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 82.96 cM
Mapping Data

1 experiment

SNPs within 2kb

2409 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443265	protein coding gene	Chr11:117544529-117654265 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019448	protein coding gene	Chr11:121922430-122042983 (+)
A/J	MGP_AJ_G0019416	protein coding gene	Chr11:116522941-116633355 (+)
AKR/J	MGP_AKRJ_G0019386	protein coding gene	Chr11:120069690-120182707 (+)
BALB/cJ	MGP_BALBcJ_G0019391	protein coding gene	Chr11:116894250-117005851 (+)
C3H/HeJ	MGP_C3HHeJ_G0019197	protein coding gene	Chr11:120346625-120460538 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019840	protein coding gene	Chr11:125639173-125764461 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017465	protein coding gene	Chr11:113536068-113641968 (+)
CAST/EiJ	MGP_CASTEiJ_G0018751	protein coding gene	Chr11:121781438-121896264 (+)
CBA/J	MGP_CBAJ_G0019168	protein coding gene	Chr11:130598780-130717301 (+)
DBA/2J	MGP_DBA2J_G0019280	protein coding gene	Chr11:115925299-116034064 (+)
FVB/NJ	MGP_FVBNJ_G0019272	protein coding gene	Chr11:115541905-115654247 (+)
LP/J	MGP_LPJ_G0019350	protein coding gene	Chr11:122250386-122367126 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019305	protein coding gene	Chr11:129570628-129685464 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019879	protein coding gene	Chr11:120714350-120829995 (+)
PWK/PhJ	MGP_PWKPhJ_G0018517	protein coding gene	Chr11:117278955-117390651 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018309	protein coding gene	Chr11:120441706-120560443 (+)
WSB/EiJ	MGP_WSBEiJ_G0018803	protein coding gene	Chr11:120686924-120799949 (+)

Human Ortholog

TNRC6C, trinucleotide repeat containing adaptor 6C

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNRC6C, trinucleotide repeat containing adaptor 6C
Links

HGNC:29318

NCBI Gene ID: 57690

neXtProt AC: NX_Q9HCJ0

UniProt: Q9HCJ0
Chr Location

17q25.3; chr17:77957557-78108835 (+) GRCh38

MGI Vertebrate Homology

Tnrc6c stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TNRC6C
Gene Tree

Tnrc6c

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

73
Endonuclease-mediated

3
Gene trapped

67
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

148 strains or lines available

Mice homozygous for a gene trap allele exhibit complete neonatal lethality with cyanosis, respiratory distress and thickened mesenchyme in air sacs.

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

29
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tnrc6c

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All Sequences

68
RefSeq

20
UniProt

3
CCDS

CCDS36381.1

Ensembl

ENSMUSG00000025571 (Evidence)
NCBI Gene

217351

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025571	Ensembl Gene Model \| MGI Sequence Detail	109151	C57BL/6J	± kb
transcript	ENSMUST00000106344	Ensembl \| MGI Sequence Detail	8847	Not Applicable
polypeptide	ENSMUSP00000101951	Ensembl \| MGI Sequence Detail	1900	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016520 trinucleotide repeat-containing gene 6C protein

(term hierarchy)
InterPro Domains

IPR019486 Argonaute hook domain

IPR052068 GW182 domain-containing protein

IPR026805 GW182, middle domain

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR034927 TNRC6C, RNA recognition motif

IPR032226 TNRC6, PABC binding domain

IPR041917 Trinucleotide repeat-containing gene 6C protein, UBA domain

IPR009060 UBA-like superfamily

IPR015940 Ubiquitin-associated domain
GlyGen

Q3UHC0 11 sites, 1 O-linked glycan (11 sites)

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All nucleic 16

Genomic 2

cDNA 10

Primer pair 3

Other 1

Microarray probesets 7

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 12
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tnrc6c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106063	Chr11:117545037-117545084 (+)	-54 bp
Tssr3743	Chr11:117545547-117545567 (+)	442 bp
Tssr106064	Chr11:117545624-117545650 (+)	522 bp
Tssr106065	Chr11:117556329-117556340 (+)	11,220 bp
Tssr106066	Chr11:117653041-117653046 (+)	107,929 bp
Tssr106067	Chr11:117653265-117653284 (+)	108,160 bp
Tssr106068	Chr11:117653324-117653339 (+)	108,217 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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