Dab2ip MGI Mouse Gene Detail - MGI:1916851 - disabled 2 interacting protein

Symbol

Dab2ip
Name

disabled 2 interacting protein
Synonyms

2310011D08Rik, AIP1, mKIAA1743

Feature Type

protein coding gene
IDs

MGI:1916851
NCBI Gene: 69601
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr2:35448285-35621006 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 23.74 cM
Mapping Data

2 experiments

SNPs within 2kb

3916 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916851	protein coding gene	Chr2:35448278-35621006 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025656	protein coding gene	Chr2:34204602-34388290 (+)
A/J	MGP_AJ_G0025633	protein coding gene	Chr2:32753922-32927920 (+)
AKR/J	MGP_AKRJ_G0025603	protein coding gene	Chr2:33905031-34079750 (+)
BALB/cJ	MGP_BALBcJ_G0025630	protein coding gene	Chr2:32867224-33041938 (+)
C3H/HeJ	MGP_C3HHeJ_G0025390	protein coding gene	Chr2:33804496-33981495 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026074	protein coding gene	Chr2:35203329-35380163 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023483	protein coding gene	Chr2:31443640-31619300 (+)
CAST/EiJ	MGP_CASTEiJ_G0024852	protein coding gene	Chr2:33805716-34000091 (+)
CBA/J	MGP_CBAJ_G0025368	protein coding gene	Chr2:36541153-36734891 (+)
DBA/2J	MGP_DBA2J_G0025501	protein coding gene	Chr2:32524694-32698962 (+)
FVB/NJ	MGP_FVBNJ_G0025463	protein coding gene	Chr2:32431217-32607116 (+)
LP/J	MGP_LPJ_G0025587	protein coding gene	Chr2:34127206-34308542 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025494	protein coding gene	Chr2:36040898-36223088 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026132	protein coding gene	Chr2:33796870-33977202 (+)
PWK/PhJ	MGP_PWKPhJ_G0024600	protein coding gene	Chr2:32447722-32638641 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024400	protein coding gene	Chr2:33982707-34167317 (+)
WSB/EiJ	MGP_WSBEiJ_G0024921	protein coding gene	Chr2:34001073-34183406 (+)

Human Ortholog

DAB2IP, DAB2 interacting protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DAB2IP, DAB2 interacting protein
Synonyms

AF9Q34, AIP-1, AIP1, DIP1/2
Links

HGNC:17294

NCBI Gene ID: 153090

neXtProt AC: NX_Q5VWQ8

UniProt: Q5VWQ8
Chr Location

9q33.2; chr9:121567057-121785530 (+) GRCh38

MGI Vertebrate Homology

Dab2ip stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DAB2IP
Gene Tree

Dab2ip

Diseases

8 with human DAB2IP associations

				Human Disease	Mouse Models
				abdominal aortic aneurysm IDs abdominal aortic aneurysm DOID:7693 EFO:0004214 MESH:D017544 NCI:C27000 OMIM:100070 OMIM:609782 OMIM:611891 OMIM:614375 UMLS_CUI:C0162871
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				peripheral artery disease IDs peripheral artery disease DOID:0050830 MESH:D058729
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				pulmonary embolism IDs pulmonary embolism DOID:9477 ICD10CM:I26 MESH:D011655 NCI:C50713 UMLS_CUI:C0034065
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

52
Endonuclease-mediated

1
Gene trapped

47
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired IRE1-mediated endoplasmic reticulum (ER) stress-induced responses. Mice homozygous for a gene trap allele exhibit delayed Purkinje cell dendritogenesis.

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All GO Annotations

156
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

30
cDNA Data

155
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dab2ip

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All Sequences

139
RefSeq

66
UniProt

10
CCDS

CCDS15965.2, CCDS50577.1, CCDS50578.1, CCDS71045.1, CCDS79788.1

Ensembl

ENSMUSG00000026883 (Evidence)
NCBI Gene

69601

			Length	Strain/Species	Flank
genomic	69601	NCBI Gene Model \| MGI Sequence Detail	172722	C57BL/6J	± kb
transcript	NM_001290641	RefSeq \| MGI Sequence Detail	6673	C57BL/6
polypeptide	Q3UHC7	UniProt \| EBI \| MGI Sequence Detail	1189	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000006260 disabled homolog 2-interacting protein

(term hierarchy)
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR021887 Disabled homolog 2-interacting protein, C-terminal domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR001936 Ras GTPase-activating domain

IPR039360 Ras GTPase-activating protein

IPR023152 Ras GTPase-activating protein, conserved site

IPR008936 Rho GTPase activation protein
GlyGen

Q3UHC7 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 157

Genomic 2

cDNA 155

Microarray probesets 3

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MGI:2138979

Summaries

All 50

Developmental Gene Expression 6

Gene Ontology 15

Phenotypes 18
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Dab2ip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17474	Chr2:35448464-35448499 (+)	197 bp
Tssr17475	Chr2:35452758-35452762 (+)	4,475 bp
Tssr17476	Chr2:35452770-35452783 (+)	4,492 bp
Tssr17477	Chr2:35471614-35471663 (+)	23,354 bp
Tssr17478	Chr2:35472841-35472863 (+)	24,567 bp
Tssr17479	Chr2:35512011-35512016 (+)	63,729 bp
Tssr17480	Chr2:35512022-35512075 (+)	63,764 bp
Tssr17481	Chr2:35512210-35512212 (+)	63,926 bp
Tssr17482	Chr2:35551280-35551302 (+)	103,006 bp
Tssr17483	Chr2:35551308-35551381 (+)	103,060 bp
Tssr17484	Chr2:35551497-35551530 (+)	103,229 bp
Tssr17485	Chr2:35553648-35553663 (+)	105,371 bp
Tssr17486	Chr2:35570579-35570584 (+)	122,297 bp
Tssr17487	Chr2:35581905-35581965 (+)	133,650 bp
Tssr17488	Chr2:35603186-35603195 (+)	154,906 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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