Gtpbp2 MGI Mouse Gene Detail - MGI:1860138

Symbol

Gtpbp2
Name

GTP binding protein 2
Synonyms

nmf205

Feature Type

protein coding gene
IDs

MGI:1860138
NCBI Gene: 56055
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr17:46471958-46480296 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 22.89 cM, cytoband C-D
Mapping Data

3 experiments

SNPs within 2kb

189 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860138	protein coding gene	Chr17:46470153-46480296 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023804	protein coding gene	Chr17:47207081-47215416 (+)
A/J	MGP_AJ_G0023762	protein coding gene	Chr17:46069406-46077744 (+)
AKR/J	MGP_AKRJ_G0023733	protein coding gene	Chr17:46403936-46412274 (+)
BALB/cJ	MGP_BALBcJ_G0023766	protein coding gene	Chr17:45973720-45982064 (+)
C3H/HeJ	MGP_C3HHeJ_G0023530	protein coding gene	Chr17:47130751-47139089 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024209	protein coding gene	Chr17:49251463-49259801 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021659	protein coding gene	Chr17:42870653-42879259 (+)
CAST/EiJ	MGP_CASTEiJ_G0023011	protein coding gene	Chr17:47253704-47267306 (+)
CBA/J	MGP_CBAJ_G0023506	protein coding gene	Chr17:51005439-51013767 (+)
DBA/2J	MGP_DBA2J_G0023632	protein coding gene	Chr17:44859880-44868218 (+)
FVB/NJ	MGP_FVBNJ_G0023599	protein coding gene	Chr17:44461763-44470098 (+)
LP/J	MGP_LPJ_G0023713	protein coding gene	Chr17:47875283-47883679 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023628	protein coding gene	Chr17:50571371-50583185 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024254	protein coding gene	Chr17:46753935-46762293 (+)
PWK/PhJ	MGP_PWKPhJ_G0022756	protein coding gene	Chr17:44175775-44184140 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022571	protein coding gene	Chr17:43654379-43662689 (+)
WSB/EiJ	MGP_WSBEiJ_G0023076	protein coding gene	Chr17:47305298-47313638 (+)

Human Ortholog

GTPBP2, GTP binding protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GTPBP2, GTP binding protein 2
Synonyms

JABELS
Links

HGNC:4670

NCBI Gene ID: 54676

neXtProt AC: NX_Q9BX10

UniProt: Q9BX10
Chr Location

6p21.1; chr6:43605316-43631333 (-) GRCh38

MGI Vertebrate Homology

Gtpbp2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GTPBP2
Gene Tree

Gtpbp2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
19 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

31
cDNA Data

109
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gtpbp2

ZFIN gtpbp2b

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All Sequences

94
RefSeq

27
UniProt

6
CCDS

CCDS50122.1

Ensembl

ENSMUSG00000023952 (Evidence)
NCBI Gene

56055

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023952	Ensembl Gene Model \| MGI Sequence Detail	8339	C57BL/6J	± kb
transcript	ENSMUST00000172170	Ensembl \| MGI Sequence Detail	2587	Not Applicable
polypeptide	ENSMUSP00000128517	Ensembl \| MGI Sequence Detail	604	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008334 GTP-binding protein 2

(term hierarchy)
InterPro Domains

IPR050055 Elongation factor Tu GTPase

IPR035531 GTP binding protein 1-like, GTP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR000795 Translational (tr)-type GTP-binding domain

IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal

IPR009000 Translation protein, beta-barrel domain superfamily

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All nucleic 109

cDNA 109

Microarray probesets 7

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MGI:2681952

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 19
Earliest

J:62657 Kudo H, et al., Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase. Biochem Biophys Res Commun. 2000 Jun 7;272(2):456-65
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gtpbp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144818	Chr17:46470138-46470149 (+)	-1,814 bp
Tssr144819	Chr17:46470194-46470203 (+)	-1,759 bp
Tssr144820	Chr17:46470491-46470537 (+)	-1,444 bp
Tssr144821	Chr17:46471487-46471503 (+)	-463 bp
Tssr144822	Chr17:46471947-46471998 (+)	15 bp
Tssr144823	Chr17:46472000-46472011 (+)	48 bp
Tssr144824	Chr17:46472052-46472074 (+)	105 bp
Tssr144825	Chr17:46472075-46472094 (+)	127 bp
Tssr144826	Chr17:46474001-46474047 (+)	2,066 bp
Tssr144827	Chr17:46474079-46474109 (+)	2,136 bp
Tssr144828	Chr17:46474128-46474151 (+)	2,182 bp
Tssr144829	Chr17:46474158-46474178 (+)	2,210 bp
Tssr144830	Chr17:46474382-46474412 (+)	2,439 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24