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Tgfbrap1 Gene Detail
Summary
  • Symbol
    Tgfbrap1
  • Name
    transforming growth factor, beta receptor associated protein 1
  • Synonyms
    3110018K12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447427
    NCBI Gene: 73122
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:43086360-43137788 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 22.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1509 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447427
 protein coding gene Chr1:43086360-43137797 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015977
 protein coding gene Chr1:42009292-42065717 (-)
A/J MGP_AJ_G0015961
 protein coding gene Chr1:40754793-40805434 (-)
AKR/J MGP_AKRJ_G0015916
 protein coding gene Chr1:41285566-41339392 (-)
BALB/cJ MGP_BALBcJ_G0015915
 protein coding gene Chr1:40427910-40480425 (-)
C3H/HeJ MGP_C3HHeJ_G0015748
 protein coding gene Chr1:41666229-41720224 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016368
 protein coding gene Chr1:43744396-43799360 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014090
 protein coding gene Chr1:37587185-37638012 (-)
CAST/EiJ MGP_CASTEiJ_G0015329
 protein coding gene Chr1:41652348-41706996 (-)
CBA/J MGP_CBAJ_G0015720
 protein coding gene Chr1:45023298-45079878 (-)
DBA/2J MGP_DBA2J_G0015821
 protein coding gene Chr1:40029819-40081575 (-)
FVB/NJ MGP_FVBNJ_G0015823
 protein coding gene Chr1:39559021-39609373 (-)
LP/J MGP_LPJ_G0015891
 protein coding gene Chr1:42359589-42411405 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015843
 protein coding gene Chr1:47017887-47073023 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016415
 protein coding gene Chr1:41497582-41552426 (-)
PWK/PhJ MGP_PWKPhJ_G0015112
 protein coding gene Chr1:39912830-39965721 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014894
 protein coding gene Chr1:41489777-41546491 (-)
WSB/EiJ MGP_WSBEiJ_G0015391
 protein coding gene Chr1:41536818-41589056 (-)



Homology
more
  • Human Ortholog
    TGFBRAP1, transforming growth factor beta receptor associated protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGFBRAP1, transforming growth factor beta receptor associated protein 1
  • Synonyms
    TRAP-1, TRAP1, VPS3
  • Links
    NCBI Gene ID: 9392
    neXtProt AC: NX_Q8WUH2
    UniProt: Q8WUH2

  • Chr Location
    2q12.1-q12.2; chr2:105249404-105329735 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice exhibit embryonic lethality between E2.5 and E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    22
  • cDNA Data
    68
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 73122 NCBI Gene Model | MGI Sequence Detail 51429 C57BL/6J ±  kb
transcript NM_001013025 RefSeq | MGI Sequence Detail 5631 C57BL/6  
polypeptide Q3UR70 UniProt | EBI | MGI Sequence Detail 860 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003163 transforming growth factor-beta receptor-associated protein 1
    (term hierarchy)
  • InterPro Domains
    IPR001180 Citron homology (CNH) domain
    IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
    IPR019452 Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1
    IPR019453 Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2
    IPR032914 Vam6/VPS39/TRAP1 family
Molecular
Reagents
less
  • All nucleic 70
    cDNA 68
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGI:1920372, MGI:2138478, MGI:2138496, MGI:2138624
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:312146 Davegardh C, et al., VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics. Nat Commun. 2021 Apr 23;12(1):2431
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory