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Armc2 Gene Detail
Summary
  • Symbol
    Armc2
  • Name
    armadillo repeat containing 2
  • Synonyms
    2610018I05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916449
    NCBI Gene: 213402
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:41790986-41894438 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 22.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2915 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916449
 protein coding gene Chr10:41784284-41894438 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017182
 protein coding gene Chr10:40581633-40693063 (-)
A/J MGP_AJ_G0017159
 protein coding gene Chr10:39446532-39555685 (-)
AKR/J MGP_AKRJ_G0017119
 protein coding gene Chr10:40055595-40164694 (-)
BALB/cJ MGP_BALBcJ_G0017121
 protein coding gene Chr10:39517321-39621553 (-)
C3H/HeJ MGP_C3HHeJ_G0016942
 protein coding gene Chr10:40369752-40490530 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017580
 protein coding gene Chr10:41817664-41932753 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015276
 protein coding gene Chr10:37335635-37439933 (-)
CAST/EiJ MGP_CASTEiJ_G0016521
 protein coding gene Chr10:40570747-40678162 (-)
CBA/J MGP_CBAJ_G0016916
 protein coding gene Chr10:43731012-43850152 (-)
DBA/2J MGP_DBA2J_G0017021
 protein coding gene Chr10:38948276-39054231 (-)
FVB/NJ MGP_FVBNJ_G0017016
 protein coding gene Chr10:38441476-38545982 (-)
LP/J MGP_LPJ_G0017098
 protein coding gene Chr10:40577787-40687445 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017046
 protein coding gene Chr10:44525550-44632180 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017617
 protein coding gene Chr10:40012092-40119848 (-)
PWK/PhJ MGP_PWKPhJ_G0016301
 protein coding gene Chr10:38821567-38931170 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016085
 protein coding gene Chr10:39839847-39946914 (-)
WSB/EiJ MGP_WSBEiJ_G0016584
 protein coding gene Chr10:40340147-40448346 (-)



Homology
more
  • Human Ortholog
    ARMC2, armadillo repeat containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARMC2, armadillo repeat containing 2
  • Synonyms
    bA787I22.1, SPGF38
  • Links
    NCBI Gene ID: 84071
    neXtProt AC: NX_Q8NEN0
    UniProt: Q8NEN0

  • Chr Location
    6q21; chr6:108848416-109053040 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Armc2 mouse models; 1 with human ARMC2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility, oligozoospermia, immotile sperm, and teratozoospermia associated with severe sperm flagellum malformations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    14
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071324 Ensembl Gene Model | MGI Sequence Detail 103453 C57BL/6J ±  kb
    transcript ENSMUST00000160262 Ensembl | MGI Sequence Detail 4810 Not Applicable  
    polypeptide ENSMUSP00000125412 Ensembl | MGI Sequence Detail 854 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 5
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory