Lgr6 MGI Mouse Gene Detail - MGI:2441805 - leucine-rich repeat-containing G protein-coupled receptor 6

Symbol

Lgr6
Name

leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms

A530037C04Rik

Feature Type

protein coding gene
IDs

MGI:2441805
NCBI Gene: 329252
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:134911039-135033014 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 58.24 cM
Mapping Data

3 experiments

SNPs within 2kb

3344 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441805	protein coding gene	Chr1:134911038-135033112 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016515	protein coding gene	Chr1:138710388-138840813 (-)
A/J	MGP_AJ_G0016498	protein coding gene	Chr1:133471228-133595229 (-)
AKR/J	MGP_AKRJ_G0016463	protein coding gene	Chr1:137450527-137575875 (-)
BALB/cJ	MGP_BALBcJ_G0016458	protein coding gene	Chr1:133788275-133911215 (-)
C3H/HeJ	MGP_C3HHeJ_G0016284	protein coding gene	Chr1:137542352-137669341 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016919	protein coding gene	Chr1:143733959-143864270 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014630	protein coding gene	Chr1:126586353-126709738 (-)
CAST/EiJ	MGP_CASTEiJ_G0015864	protein coding gene	Chr1:136614571-136740789 (-)
CBA/J	MGP_CBAJ_G0016257	protein coding gene	Chr1:148686502-148825361 (-)
DBA/2J	MGP_DBA2J_G0016363	protein coding gene	Chr1:132475587-132599438 (-)
FVB/NJ	MGP_FVBNJ_G0016362	protein coding gene	Chr1:131111796-131234820 (-)
LP/J	MGP_LPJ_G0016434	protein coding gene	Chr1:139955128-140084021 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016387	protein coding gene	Chr1:154392807-154525521 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016955	protein coding gene	Chr1:137192072-137319050 (-)
PWK/PhJ	MGP_PWKPhJ_G0015650	protein coding gene	Chr1:131497108-131621712 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015437	protein coding gene	Chr1:136157556-136282197 (-)
WSB/EiJ	MGP_WSBEiJ_G0015927	protein coding gene	Chr1:137218742-137347659 (-)

Human Ortholog

LGR6, leucine rich repeat containing G protein-coupled receptor 6

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LGR6, leucine rich repeat containing G protein-coupled receptor 6
Synonyms

GPCR, VTS20631
Links

HGNC:19719

NCBI Gene ID: 59352

neXtProt AC: NX_Q9HBX8

UniProt: Q9HBX8
Chr Location

1q32.1; chr1:202193799-202319781 (+) GRCh38

MGI Vertebrate Homology

Lgr6 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LGR6
Gene Tree

Lgr6

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
49 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Endonuclease-mediated

6
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Lgr6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

86 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a reporter/null allele are viable and fertile with no apparent abnormal phenotype. Similarly, mice homozygous for a knock-in allele are healthy and fertile.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

918
Tissues

81
cDNA Data

21
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

17
UniProt

2
CCDS

CCDS15314.1

Ensembl

ENSMUSG00000042793 (Evidence)
NCBI Gene

329252

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042793	Ensembl Gene Model \| MGI Sequence Detail	121976	C57BL/6J	± kb
transcript	ENSMUST00000044828	Ensembl \| MGI Sequence Detail	6675	Not Applicable
polypeptide	ENSMUSP00000035444	Ensembl \| MGI Sequence Detail	967	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001593 leucine-rich repeat-containing G-protein coupled receptor 6

(term hierarchy)
InterPro Domains

IPR002131 Glycoprotein hormone receptor family

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype
GlyGen

Q3UVD5 2 sites, 1 N-linked glycan (1 site)

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All nucleic 35

Genomic 2

cDNA 21

Primer pair 7

Other 5

Microarray probesets 2

Summaries

All 97

Developmental Gene Expression 23

Gene Ontology 8

Phenotypes 49
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:353997 Zhao M, et al., Cardiomyocyte LGR6 alleviates ferroptosis in diabetic cardiomyopathy via regulating mitochondrial biogenesis. Metabolism. 2024 Oct;159:155979

TSS for Lgr6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13819	Chr1:135033089-135033100 (-)	-81 bp
Tssr13818	Chr1:135033071-135033087 (-)	-65 bp
Tssr219	Chr1:135032972-135032975 (-)	40 bp
Tssr13817	Chr1:135032948-135032963 (-)	58 bp
Tssr13816	Chr1:135032917-135032945 (-)	83 bp
Tssr13815	Chr1:135032897-135032908 (-)	111 bp
Tssr13814	Chr1:134912756-134912763 (-)	120,254 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24