Clpsl2 MGI Mouse Gene Detail - MGI:2685595

Symbol

Clpsl2
Name

colipase-like 2
Synonyms

Gm749, LOC328788

Feature Type

protein coding gene
IDs

MGI:2685595
NCBI Gene: 328788
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:28768461-28771592 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 14.75 cM
Mapping Data

1 experiment

SNPs within 2kb

1 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685595	protein coding gene	Chr17:28768385-28771594 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023443	protein coding gene	Chr17:27973133-27977440 (+)
A/J	MGP_AJ_G0023401	protein coding gene	Chr17:27033533-27036576 (+)
AKR/J	MGP_AKRJ_G0023366	protein coding gene	Chr17:27243556-27248224 (+)
BALB/cJ	MGP_BALBcJ_G0023406	protein coding gene	Chr17:27311068-27322002 (+)
C3H/HeJ	MGP_C3HHeJ_G0023167	protein coding gene	Chr17:27638548-27647250 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023848	protein coding gene	Chr17:29097926-29104979 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021323	protein coding gene	Chr17:24400136-24403784 (+)
CAST/EiJ	MGP_CASTEiJ_G0022668	protein coding gene	Chr17:27609127-27612107 (+)
CBA/J	MGP_CBAJ_G0023141	protein coding gene	Chr17:30148919-30154542 (+)
DBA/2J	MGP_DBA2J_G0023272	protein coding gene	Chr17:26592221-26596262 (+)
FVB/NJ	MGP_FVBNJ_G0023242	protein coding gene	Chr17:26406472-26415390 (+)
LP/J	MGP_LPJ_G0023350	protein coding gene	Chr17:28226830-28231230 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023260	protein coding gene	Chr17:29558140-29562356 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023890	protein coding gene	Chr17:27682127-27685233 (+)
PWK/PhJ	MGP_PWKPhJ_G0022418	protein coding gene	Chr17:25410118-25414136 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022236	protein coding gene	Chr17:25662690-25669012 (+)
WSB/EiJ	MGP_WSBEiJ_G0022730	protein coding gene	Chr17:27672616-27677687 (+)

Human Ortholog

CLPSL2, colipase like 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLPSL2, colipase like 2
Synonyms

AAAL3045, C6orf126, dJ510O8.5, UNQ3045
Links

HGNC:21250

NCBI Gene ID: 389383

neXtProt AC: NX_Q6UWE3

UniProt: Q6UWE3
Chr Location

6p21.31

MGI Vertebrate Homology

Clpsl2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CLPSL2
Gene Tree

Clpsl2

less

Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

6
Gene trapped

3
Targeted

1
Incidental Mutations

CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice exhibit normal spermatozoa and fecundity.

less

All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

29
RefSeq

3
UniProt

1
CCDS

CCDS50047.1

Ensembl

ENSMUSG00000024224 (Evidence)
NCBI Gene

328788

			Length	Strain/Species	Flank
genomic	328788	NCBI Gene Model \| MGI Sequence Detail	3132	C57BL/6J	± kb
transcript	NM_001034871	RefSeq \| MGI Sequence Detail	444	C57BL/6
polypeptide	Q3UW21	UniProt \| EBI \| MGI Sequence Detail	102	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000031279 colipase-like protein 2

(term hierarchy)
InterPro Domains

IPR001981 Colipase

less

All nucleic 5

cDNA 5

Microarray probesets 1

Summaries

All 26

Gene Ontology 3

Phenotypes 9
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:279041 Noda T, et al., Nine genes abundantly expressed in the epididymis are not essential for male fecundity in mice. Andrology. 2019;

TSS for Clpsl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143440	Chr17:28768445-28768456 (+)	-10 bp
Tssr143441	Chr17:28768460-28768476 (+)	7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24