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Kdm7a Gene Detail
Summary
  • Symbol
    Kdm7a
  • Name
    lysine (K)-specific demethylase 7A
  • Synonyms
    A630082K20Rik, ENSMUSG00000073143, Jhdm1d, Kdm7a, mKIAA1718
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443388
    NCBI Gene: 338523
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:39113554-39183707 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 17.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1545 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443388
 protein coding gene Chr6:39113554-39183723 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030594
 protein coding gene Chr6:37492001-37564066 (-)
A/J MGP_AJ_G0030567
 protein coding gene Chr6:35859069-35930721 (-)
AKR/J MGP_AKRJ_G0030494
 protein coding gene Chr6:36999629-37072974 (-)
BALB/cJ MGP_BALBcJ_G0030577
 protein coding gene Chr6:36071611-36143250 (-)
C3H/HeJ MGP_C3HHeJ_G0030290
 protein coding gene Chr6:37009679-37082394 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031031
 protein coding gene Chr6:38413502-38488047 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028243
 protein coding gene Chr6:33761357-33829810 (-)
CAST/EiJ MGP_CASTEiJ_G0029692
 protein coding gene Chr6:36915327-36989067 (-)
CBA/J MGP_CBAJ_G0030268
 protein coding gene Chr6:39922709-40003151 (-)
DBA/2J MGP_DBA2J_G0030412
 protein coding gene Chr6:35687097-35755875 (-)
FVB/NJ MGP_FVBNJ_G0030366
 protein coding gene Chr6:35466477-35536016 (-)
LP/J MGP_LPJ_G0030499
 protein coding gene Chr6:37520653-37597216 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030402
 protein coding gene Chr6:42287946-42359485 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031061
 protein coding gene Chr6:36933942-37007356 (-)
PWK/PhJ MGP_PWKPhJ_G0029406
 protein coding gene Chr6:35359027-35430194 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029242
 protein coding gene Chr6:36670723-36743292 (-)
WSB/EiJ MGP_WSBEiJ_G0029768
 protein coding gene Chr6:36878890-36954599 (-)



Homology
more
  • Human Ortholog
    KDM7A, lysine demethylase 7A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDM7A, lysine demethylase 7A
  • Synonyms
    JHDM1D
  • Links
    NCBI Gene ID: 80853
    neXtProt AC: NX_Q6ZMT4
    UniProt: Q6ZMT4

  • Chr Location
    7q34; chr7:140084746-140176983 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KDM7A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit abnormal hair follicle, tail, sebaceous gland, rib, and vertebrae morphology and decreased circulating iron levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    17
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 338523 NCBI Gene Model | MGI Sequence Detail 70154 C57BL/6J ±  kb
    transcript NM_001033430 RefSeq | MGI Sequence Detail 9460 C57BL/6  
    polypeptide Q3UWM4 UniProt | EBI | MGI Sequence Detail 940 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141725, MGI:3642369
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/05/2024
    MGI 6.24     		The Jackson Laboratory