Slc25a31 MGI Mouse Gene Detail - MGI:1920583 - solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31

Symbol

Slc25a31
Name

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
Synonyms

1700034J06Rik

Feature Type

protein coding gene
IDs

MGI:1920583
NCBI Gene: 73333
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:40663301-40680525 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 19.50 cM
Mapping Data

1 experiment

SNPs within 2kb

462 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920583	protein coding gene	Chr3:40663285-40680527 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027178	protein coding gene	Chr3:38670995-38689116 (+)
A/J	MGP_AJ_G0027138	protein coding gene	Chr3:37723927-37741602 (+)
AKR/J	MGP_AKRJ_G0027107	protein coding gene	Chr3:38442707-38461355 (+)
BALB/cJ	MGP_BALBcJ_G0027150	protein coding gene	Chr3:37479217-37497240 (+)
C3H/HeJ	MGP_C3HHeJ_G0026893	protein coding gene	Chr3:38529278-38546502 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027596	protein coding gene	Chr3:40257199-40272868 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024957	protein coding gene	Chr3:35291622-35309692 (+)
CAST/EiJ	MGP_CASTEiJ_G0026346	protein coding gene	Chr3:38438211-38455839 (-)
CBA/J	MGP_CBAJ_G0026870	protein coding gene	Chr3:41429612-41449737 (+)
DBA/2J	MGP_DBA2J_G0027004	protein coding gene	Chr3:37184611-37200884 (+)
FVB/NJ	MGP_FVBNJ_G0026972	protein coding gene	Chr3:36591339-36607395 (+)
LP/J	MGP_LPJ_G0027116	protein coding gene	Chr3:39411888-39428314 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026991	protein coding gene	Chr3:43873727-43891875 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027655	protein coding gene	Chr3:38332019-38350926 (+)
PWK/PhJ	MGP_PWKPhJ_G0026079	protein coding gene	Chr3:36846651-36859320 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025891	protein coding gene	Chr3:37676731-37695039 (+)
WSB/EiJ	MGP_WSBEiJ_G0026420	protein coding gene	Chr3:38328431-38343966 (+)

Human Ortholog

SLC25A31, solute carrier family 25 member 31

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC25A31, solute carrier family 25 member 31
Synonyms

AAC4, ANT 4, ANT4, SFEC35kDa
Links

HGNC:25319

NCBI Gene ID: 83447

neXtProt AC: NX_Q9H0C2

UniProt: Q9H0C2
Chr Location

4q28.1; chr4:127730400-127774292 (+) GRCh38

MGI Vertebrate Homology

Slc25a31 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLC25A31
Gene Tree

Slc25a31

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Radiation induced

2
Targeted

2
Genomic Mutations

2 involving Slc25a31
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a null allele exhibit infertility, arrested meiosis and increased apoptosis of the spermatocytes.

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All GO Annotations

15
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

877
Tissues

117
cDNA Data

10
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS17326.1

Ensembl

ENSMUSG00000069041 (Evidence)
NCBI Gene

73333

			Length	Strain/Species	Flank
genomic	73333	NCBI Gene Model \| MGI Sequence Detail	17225	C57BL/6J	± kb
transcript	NM_178386	RefSeq \| MGI Sequence Detail	2110	C57BL/6
polypeptide	Q3V132	UniProt \| EBI \| MGI Sequence Detail	320	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015028 ADP/ATP translocase 4

(term hierarchy)
InterPro Domains

IPR002113 ADP/ATP carrier protein, eukaryotic type

IPR023395 Mitochondrial carrier domain superfamily

IPR002067 Mitochondrial carrier protein

IPR018108 Mitochondrial substrate/solute carrier

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All nucleic 13

cDNA 10

Primer pair 3

Microarray probesets 2

Summaries

All 43

Developmental Gene Expression 6

Diseases 1

Gene Ontology 9

Phenotypes 16
Earliest

J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
Latest

J:339634 Bround MJ, et al., ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy. Sci Adv. 2023 Aug 25;9(34):eadi2767

TSS for Slc25a31:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28956	Chr3:40663289-40663336 (+)	12 bp
Tssr28957	Chr3:40663346-40663367 (+)	56 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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