Qrich2 MGI Mouse Gene Detail - MGI:2684912

Symbol

Qrich2
Name

glutamine rich 2
Synonyms

LOC217341

Feature Type

protein coding gene
IDs

MGI:2684912
NCBI Gene: 217341
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:116332151-116357067 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 81.30 cM
Mapping Data

1 experiment

SNPs within 2kb

655 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684912	protein coding gene	Chr11:116332149-116357092 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019428	protein coding gene	Chr11:120550857-120566637 (-)
A/J	MGP_AJ_G0019396	protein coding gene	Chr11:115283619-115298387 (-)
AKR/J	MGP_AKRJ_G0019367	protein coding gene	Chr11:118721663-118735557 (-)
BALB/cJ	MGP_BALBcJ_G0019371	protein coding gene	Chr11:115690589-115704552 (-)
C3H/HeJ	MGP_C3HHeJ_G0019177	protein coding gene	Chr11:119068657-119083929 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019820	protein coding gene	Chr11:124245656-124259581 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017444	protein coding gene	Chr11:112289288-112304199 (-)
CAST/EiJ	MGP_CASTEiJ_G0018732	protein coding gene	Chr11:120441395-120455417 (-)
CBA/J	MGP_CBAJ_G0019148	protein coding gene	Chr11:129151257-129169092 (-)
DBA/2J	MGP_DBA2J_G0019260	protein coding gene	Chr11:114716621-114730476 (-)
FVB/NJ	MGP_FVBNJ_G0019252	protein coding gene	Chr11:114224427-114238587 (-)
LP/J	MGP_LPJ_G0019330	protein coding gene	Chr11:120936571-120953048 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019285	protein coding gene	Chr11:128212806-128227636 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019859	protein coding gene	Chr11:119376614-119390535 (-)
PWK/PhJ	MGP_PWKPhJ_G0018496	protein coding gene	Chr11:116034262-116048529 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018289	protein coding gene	Chr11:119130523-119143833 (-)
WSB/EiJ	MGP_WSBEiJ_G0018784	protein coding gene	Chr11:119346988-119362451 (-)

Human Ortholog

QRICH2, glutamine rich 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

QRICH2, glutamine rich 2
Synonyms

SPGF35
Links

HGNC:25326

NCBI Gene ID: 84074

neXtProt AC: NX_Q9H0J4

UniProt: Q9H0J4
Chr Location

17q25.1; chr17:76274049-76310964 (-) GRCh38

MGI Vertebrate Homology

Qrich2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: QRICH2
Gene Tree

Qrich2

Diseases

1 with human QRICH2 associations

				Human Disease	Mouse Models
				spermatogenic failure 35 IDs spermatogenic failure 35 DOID:0111914 OMIM:618341

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
1 phenotype reference

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Endonuclease-mediated

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility associated with decreased epididymis weight, multiple morphological abnormalities of the sperm flagella, oligozoospermia, and asthenozoospermia.

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All GO Annotations

14
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase qrich2

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All Sequences

50
RefSeq

18
UniProt

2
CCDS

CCDS25667.1

Ensembl

ENSMUSG00000070331 (Evidence)
NCBI Gene

217341

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070331	Ensembl Gene Model \| MGI Sequence Detail	24917	C57BL/6J	± kb
transcript	ENSMUST00000208602	Ensembl \| MGI Sequence Detail	7260	Not Applicable
polypeptide	ENSMUSP00000147009	Ensembl \| MGI Sequence Detail	2337	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013570 glutamine-rich protein 2

(term hierarchy)
InterPro Domains

IPR032013 Domain of unknown function DUF4795

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All nucleic 12

cDNA 12

Microarray probesets 2

Summaries

All 21

Gene Ontology 4

Phenotypes 1
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:270177 Shen Y, et al., Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella. Nat Commun. 2019 Jan 25;10(1):433

TSS for Qrich2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111928	Chr11:116357075-116357077 (-)	-9 bp
Tssr111927	Chr11:116357045-116357067 (-)	11 bp
Tssr111926	Chr11:116357024-116357028 (-)	41 bp
Tssr111925	Chr11:116350783-116350798 (-)	6,276 bp
Tssr111924	Chr11:116350756-116350773 (-)	6,302 bp
Tssr111923	Chr11:116339220-116339232 (-)	17,841 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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