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Dync2h1 Gene Detail
Summary
  • Symbol
    Dync2h1
  • Name
    dynein cytoplasmic 2 heavy chain 1
  • Synonyms
    4432416O06Rik, b2b414Clo, D030010H02Rik, D330044F14Rik, DHC1b, DHC2, Dnchc2, m152Asp, m407Asp
  • Feature Type
    protein coding gene
  • IDs
    MGI:107736
    NCBI Gene: 110350
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:6928550-7177619 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, Syntenic
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5016 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107736
 protein coding gene Chr9:6928503-7184446 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034317
 protein coding gene Chr9:3775522-4040005 (-)
A/J MGP_AJ_G0034294
 protein coding gene Chr9:3862341-4120287 (-)
AKR/J MGP_AKRJ_G0034224
 protein coding gene Chr9:3758803-3996283 (-)
BALB/cJ MGP_BALBcJ_G0034288
 protein coding gene Chr9:3634189-3887923 (-)
C3H/HeJ MGP_C3HHeJ_G0034000
 protein coding gene Chr9:3962069-4220750 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034810
 protein coding gene Chr9:3912226-4194044 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031748
 protein coding gene Chr9:3216103-3454413 (-)
CAST/EiJ MGP_CASTEiJ_G0033327
 protein coding gene Chr9:3946996-4211650 (-)
CBA/J MGP_CBAJ_G0033972
 protein coding gene Chr9:4036733-4298307 (-)
DBA/2J MGP_DBA2J_G0034129
 protein coding gene Chr9:3772580-4017509 (-)
FVB/NJ MGP_FVBNJ_G0034074
 protein coding gene Chr9:3567142-3810366 (-)
LP/J MGP_LPJ_G0034216
 protein coding gene Chr9:3834196-4093017 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034118
 protein coding gene Chr9:4719247-5012282 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034829
 protein coding gene Chr9:3738862-3998354 (-)
PWK/PhJ MGP_PWKPhJ_G0033031
 protein coding gene Chr9:3926014-4172387 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032868
 protein coding gene Chr9:4027626-4270742 (-)
WSB/EiJ MGP_WSBEiJ_G0033443
 protein coding gene Chr9:3744675-4004540 (-)



Homology
more
  • Human Ortholog
    DYNC2H1, dynein cytoplasmic 2 heavy chain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYNC2H1, dynein cytoplasmic 2 heavy chain 1
  • Synonyms
    ATD3, DHC1b, DHC2, DNCH2, DYH1B, hdhc11, SRPS2B, SRTD3
  • Links
    NCBI Gene ID: 79659
    neXtProt AC: NX_Q8NCM8
    UniProt: Q8NCM8

  • Chr Location
    11q22.3; chr11:103109410-103479863 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Dync2h1 mouse models; 2 with human DYNC2H1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 10 alleles in 10 genetic backgrounds
    3 phenotypes from multigenic genotypes
    26 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene trap allele show complete embryonic lethality with altered heart looping and brain morphology. Chemically induced mutants show randomized heart looping and polydactyly. Holoprosencephaly or exencephaly, dorsoventral forebrain patterning defects, micrognathia, and cardiac, renal, airway and eye defects may be observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    12
  • cDNA Data
    59
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110350 NCBI Gene Model | MGI Sequence Detail 249070 C57BL/6J ±  kb
    transcript NM_029851 RefSeq | MGI Sequence Detail 13937 ZRU/MplStud  
    polypeptide Q45VK7 UniProt | EBI | MGI Sequence Detail 4306 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000006775 cytoplasmic dynein 2 heavy chain 1
      (term hierarchy)
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR049400 Cytoplasmic dynein 2 heavy chain 1, AAA+ ATPase domain
      IPR026983 Dynein heavy chain
      IPR043157 Dynein heavy chain, AAA1 domain, small subdomain
      IPR041658 Dynein heavy chain AAA lid domain
      IPR042219 Dynein heavy chain AAA lid domain superfamily
      IPR024317 Dynein heavy chain, AAA module D4
      IPR035706 Dynein heavy chain, ATP-binding dynein motor region
      IPR024743 Dynein heavy chain, coiled coil stalk
      IPR041228 Dynein heavy chain, C-terminal domain
      IPR043160 Dynein heavy chain, C-terminal domain, barrel region
      IPR042222 Dynein heavy chain, domain 2, N-terminal
      IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
      IPR013602 Dynein heavy chain, linker
      IPR042228 Dynein heavy chain, linker, subdomain 3
      IPR004273 Dynein heavy chain region D6 P-loop domain
      IPR013594 Dynein heavy chain, tail
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q45VK7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 60
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36312, MGI:1924297, MGI:2143052, MGI:2444284, MGI:2445078, MGI:3799279, MGI:3799294, MGI:5311337
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 17
      Phenotypes 29
    • Earliest
      J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory