Atad5 MGI Mouse Gene Detail - MGI:2442925 - ATPase family, AAA domain containing 5

Symbol

Atad5
Name

ATPase family, AAA domain containing 5
Synonyms

C130052G03Rik, LOC237877

Feature Type

protein coding gene
IDs

MGI:2442925
NCBI Gene: 237877
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:79980226-80026620 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 47.48 cM
Mapping Data

2 experiments

SNPs within 2kb

937 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442925	protein coding gene	Chr11:79980205-80026623 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018805	protein coding gene	Chr11:81224963-81280111 (+)
A/J	MGP_AJ_G0018772	protein coding gene	Chr11:78110806-78157974 (+)
AKR/J	MGP_AKRJ_G0018742	protein coding gene	Chr11:80456959-80504832 (+)
BALB/cJ	MGP_BALBcJ_G0018745	protein coding gene	Chr11:78499040-78546663 (+)
C3H/HeJ	MGP_C3HHeJ_G0018559	protein coding gene	Chr11:80504274-80552803 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019197	protein coding gene	Chr11:83716388-83774504 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016831	protein coding gene	Chr11:75040540-75088461 (+)
CAST/EiJ	MGP_CASTEiJ_G0018114	protein coding gene	Chr11:80985212-81034809 (+)
CBA/J	MGP_CBAJ_G0018530	protein coding gene	Chr11:87366809-87419892 (+)
DBA/2J	MGP_DBA2J_G0018638	protein coding gene	Chr11:77667127-77714501 (+)
FVB/NJ	MGP_FVBNJ_G0018627	protein coding gene	Chr11:77235944-77282663 (+)
LP/J	MGP_LPJ_G0018708	protein coding gene	Chr11:81750531-81798511 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018654	protein coding gene	Chr11:87655331-87709477 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019237	protein coding gene	Chr11:80706957-80754425 (+)
PWK/PhJ	MGP_PWKPhJ_G0017884	protein coding gene	Chr11:78471070-78517246 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017675	protein coding gene	Chr11:80295243-80345090 (+)
WSB/EiJ	MGP_WSBEiJ_G0018166	protein coding gene	Chr11:80537630-80587351 (+)

Human Ortholog

ATAD5, ATPase family AAA domain containing 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATAD5, ATPase family AAA domain containing 5
Synonyms

C17orf41, ELG1, FRAG1
Links

HGNC:25752

NCBI Gene ID: 79915

neXtProt AC: NX_Q96QE3

UniProt: Q96QE3
Chr Location

17q11.2; chr17:30831966-30895869 (+) GRCh38

MGI Vertebrate Homology

Atad5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ATAD5
Gene Tree

Atad5

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Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

35
Targeted

2
Genomic Mutations

2 involving Atad5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

100 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit prenatal lethality. Mice heterozygous for a gene trap allele exhibit genomic instability, premature death, and a wide spectrum of spontaneous tumors.

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All GO Annotations

33
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

772
Tissues

5
cDNA Data

67
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atad5

ZFIN atad5a, atad5b

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All Sequences

56
RefSeq

15
UniProt

3
CCDS

CCDS25127.1

Ensembl

ENSMUSG00000017550 (Evidence)
NCBI Gene

237877

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017550	Ensembl Gene Model \| MGI Sequence Detail	46395	C57BL/6J	± kb
transcript	ENSMUST00000017694	Ensembl \| MGI Sequence Detail	7272	Not Applicable
polypeptide	ENSMUSP00000017694	Ensembl \| MGI Sequence Detail	1826	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004394 ATPase family AAA domain-containing protein 5

(term hierarchy)
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR003959 ATPase, AAA-type, core

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q4QY64 1 site, 1 O-linked glycan (1 site)

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All nucleic 67

cDNA 67

Microarray probesets 2

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MGI:2684863

Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Atad5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103478	Chr11:79980211-79980243 (+)	1 bp
Tssr103479	Chr11:79980252-79980295 (+)	48 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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