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Maea Gene Detail
Summary
  • Symbol
    Maea
  • Name
    macrophage erythroblast attacher
  • Synonyms
    1110030D19Rik, Gid9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891748
    NCBI Gene: 59003
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:33492916-33530638 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.55 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    911 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891748
 protein coding gene Chr5:33492853-33530640 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029444
 protein coding gene Chr5:31507587-31545396 (+)
A/J MGP_AJ_G0029411
 protein coding gene Chr5:30480578-30518364 (+)
AKR/J MGP_AKRJ_G0029360
 protein coding gene Chr5:31658161-31695994 (+)
BALB/cJ MGP_BALBcJ_G0029421
 protein coding gene Chr5:31009389-31047860 (+)
C3H/HeJ MGP_C3HHeJ_G0029143
 protein coding gene Chr5:31693260-31734256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029875
 protein coding gene Chr5:33388690-33429774 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027112
 protein coding gene Chr5:28275480-28315039 (+)
CAST/EiJ MGP_CASTEiJ_G0028552
 protein coding gene Chr5:30775614-30813487 (+)
CBA/J MGP_CBAJ_G0029111
 protein coding gene Chr5:34091545-34129645 (+)
DBA/2J MGP_DBA2J_G0029259
 protein coding gene Chr5:30659713-30698059 (+)
FVB/NJ MGP_FVBNJ_G0029218
 protein coding gene Chr5:30082400-30120406 (+)
LP/J MGP_LPJ_G0029344
 protein coding gene Chr5:31924082-31961853 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029248
 protein coding gene Chr5:34948440-34988335 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029908
 protein coding gene Chr5:31172851-31212773 (+)
PWK/PhJ MGP_PWKPhJ_G0028277
 protein coding gene Chr5:29783984-29822053 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028108
 protein coding gene Chr5:30629759-30662359 (+)
WSB/EiJ MGP_WSBEiJ_G0028633
 protein coding gene Chr5:31231446-31269349 (+)



Homology
more
  • Human Ortholog
    MAEA, macrophage erythroblast attacher, E3 ubiquitin ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAEA, macrophage erythroblast attacher, E3 ubiquitin ligase
  • Synonyms
    EMLP, EMP, GID9, HLC-10, P44EMLP, PIG5
  • Links
    NCBI Gene ID: 10296
    neXtProt AC: NX_Q7L5Y9
    UniProt: Q7L5Y9

  • Chr Location
    4p16.3; chr4:1289887-1340147 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Gene trapped
    7
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    7 involving Maea
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    40 strains or lines available
Mice homozygous for a gene trapped allele die perinatally displaying reduced fetal size, pallor, reduced numbers of erythroblastic islands, defects in terminal erythroid maturation, and severely impaired terminal differentiation of fetal liver macrophages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    175
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 59003 NCBI Gene Model | MGI Sequence Detail 37723 C57BL/6J ±  kb
transcript NM_001429043 RefSeq | MGI Sequence Detail 2226 C57BL/6  
polypeptide Q4VC33 UniProt | EBI | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 175
    cDNA 175

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915075
References
more
  • Summaries
    All 69
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 8
    Phenotypes 38
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory