About   Help   FAQ
Pdp2 Gene Detail
Summary
  • Symbol
    Pdp2
  • Name
    pyruvate dehydrogenase phosphatase catalytic subunit 2
  • Synonyms
    4833426J09Rik, LOC382051
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918878
    NCBI Gene: 382051
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105318104-105325658 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918878
 protein coding gene Chr8:105318083-105325658 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034014
 protein coding gene Chr8:106742921-106748286 (+)
A/J MGP_AJ_G0033995
 protein coding gene Chr8:102522497-102527942 (+)
AKR/J MGP_AKRJ_G0033921
 protein coding gene Chr8:105484094-105489447 (+)
BALB/cJ MGP_BALBcJ_G0033988
 protein coding gene Chr8:102726813-102732175 (+)
C3H/HeJ MGP_C3HHeJ_G0033700
 protein coding gene Chr8:106192409-106196266 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034508
 protein coding gene Chr8:110659600-110664960 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031451
 protein coding gene Chr8:95771139-95776472 (+)
CAST/EiJ MGP_CASTEiJ_G0033027
 protein coding gene Chr8:105744280-105750003 (+)
CBA/J MGP_CBAJ_G0033674
 protein coding gene Chr8:114329689-114335069 (+)
DBA/2J MGP_DBA2J_G0033828
 protein coding gene Chr8:101867891-101873247 (+)
FVB/NJ MGP_FVBNJ_G0033775
 protein coding gene Chr8:100806765-100812138 (+)
LP/J MGP_LPJ_G0033919
 protein coding gene Chr8:106930943-106936305 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033817
 protein coding gene Chr8:117492052-117497409 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034526
 protein coding gene Chr8:105426118-105431473 (+)
PWK/PhJ MGP_PWKPhJ_G0032729
 protein coding gene Chr8:101277158-101282714 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032568
 protein coding gene Chr8:104239004-104244787 (+)
WSB/EiJ MGP_WSBEiJ_G0033142
 protein coding gene Chr8:106116929-106122304 (+)



Homology
more
  • Human Ortholog
    PDP2, pyruvate dehydrogenase phosphatase catalytic subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDP2, pyruvate dehydrogenase phosphatase catalytic subunit 2
  • Synonyms
    PDPC 2, PPM2B, PPM2C2
  • Links
    NCBI Gene ID: 57546
    neXtProt AC: NX_Q9P2J9
    UniProt: Q9P2J9

  • Chr Location
    16q22.1; chr16:66878589-66895754 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    4
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 382051 NCBI Gene Model | MGI Sequence Detail 7555 C57BL/6J ±  kb
    transcript NM_001024606 RefSeq | MGI Sequence Detail 5671 C57BL/6  
    polypeptide Q504M2 UniProt | EBI | MGI Sequence Detail 532 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
      3.1.3.43
    • InterPro Domains
      IPR000222 PPM-type phosphatase, divalent cation binding
      IPR001932 PPM-type phosphatase-like domain
      IPR036457 PPM-type phosphatase-like domain superfamily
      IPR015655 Protein phosphatase 2C
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2686551
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory