Cpa2 MGI Mouse Gene Detail - MGI:3617840 - carboxypeptidase A2, pancreatic

Symbol

Cpa2
Name

carboxypeptidase A2, pancreatic

Feature Type

protein coding gene
IDs

MGI:3617840
NCBI Gene: 232680
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr6:30541641-30564475 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 12.52 cM
Mapping Data

1 experiment

SNPs within 2kb

580 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3617840	protein coding gene	Chr6:30541581-30564475 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030539	protein coding gene	Chr6:28437302-28465026 (+)
A/J	MGP_AJ_G0030512	protein coding gene	Chr6:27209445-27232239 (+)
AKR/J	MGP_AKRJ_G0030439	protein coding gene	Chr6:28122029-28146267 (+)
BALB/cJ	MGP_BALBcJ_G0030522	protein coding gene	Chr6:27360272-27383521 (+)
C3H/HeJ	MGP_C3HHeJ_G0030235	protein coding gene	Chr6:28113068-28137522 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030976	protein coding gene	Chr6:29239580-29266849 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028187	protein coding gene	Chr6:25406352-25429544 (+)
CAST/EiJ	MGP_CASTEiJ_G0029637	protein coding gene	Chr6:27935047-27957826 (+)
CBA/J	MGP_CBAJ_G0030213	protein coding gene	Chr6:30350326-30377858 (+)
DBA/2J	MGP_DBA2J_G0030357	protein coding gene	Chr6:27137902-27162392 (+)
FVB/NJ	MGP_FVBNJ_G0030311	protein coding gene	Chr6:26905179-26928065 (+)
LP/J	MGP_LPJ_G0030444	protein coding gene	Chr6:28568666-28592724 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030347	protein coding gene	Chr6:32791404-32816950 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031006	protein coding gene	Chr6:27994884-28020601 (+)
PWK/PhJ	MGP_PWKPhJ_G0029351	protein coding gene	Chr6:26716163-26740629 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029187	protein coding gene	Chr6:27738173-27762717 (+)
WSB/EiJ	MGP_WSBEiJ_G0029713	protein coding gene	Chr6:27963093-27989310 (+)

Human Ortholog

CPA2, carboxypeptidase A2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CPA2, carboxypeptidase A2
Links

HGNC:2297

NCBI Gene ID: 1358

neXtProt AC: NX_P48052

UniProt: P48052
Chr Location

7q32.2; chr7:130266863-130289798 (+) GRCh38

MGI Vertebrate Homology

Cpa2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CPA2
Gene Tree

Cpa2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

11
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

10
cDNA Data

100
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN cpa2

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All Sequences

38
RefSeq

4
UniProt

1
CCDS

CCDS19974.1

Ensembl

ENSMUSG00000071553 (Evidence)
NCBI Gene

232680

			Length	Strain/Species	Flank
genomic	232680	NCBI Gene Model \| MGI Sequence Detail	22835	C57BL/6J	± kb
transcript	NM_001024698	RefSeq \| MGI Sequence Detail	1340	C57BL/6
polypeptide	Q504N0	UniProt \| EBI \| MGI Sequence Detail	417	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005796 carboxypeptidase A2

(term hierarchy)
EC

3.4.17.15
InterPro Domains

IPR034248 Carboxypeptidase A, carboxypeptidase domain

IPR003146 Carboxypeptidase, activation peptide

IPR036990 Metallocarboxypeptidase-like, propeptide

IPR000834 Peptidase M14, carboxypeptidase A

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All nucleic 101

cDNA 100

Other 1

Microarray probesets 1

Summaries

All 37

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 9
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cpa2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55347	Chr6:30541634-30541649 (+)	1 bp
Tssr55348	Chr6:30544021-30544029 (+)	2,384 bp
Tssr55349	Chr6:30544884-30544909 (+)	3,256 bp
Tssr55350	Chr6:30544985-30544996 (+)	3,350 bp
Tssr55351	Chr6:30551459-30551463 (+)	9,820 bp
Tssr55352	Chr6:30554595-30554600 (+)	12,957 bp
Tssr55353	Chr6:30560506-30560511 (+)	18,868 bp
Tssr55354	Chr6:30564397-30564415 (+)	22,765 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24