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Prag1 Gene Detail
Summary
  • Symbol
    Prag1
  • Name
    PEAK1 related kinase activating pseudokinase 1
  • Synonyms
    D8Ertd82e, NACK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196223
    NCBI Gene: 244418
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:36562015-36614939 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 22.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1685 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196223
 protein coding gene Chr8:36561982-36614941 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033542
 protein coding gene Chr8:34743139-34796252 (+)
A/J MGP_AJ_G0033522
 protein coding gene Chr8:33373294-33429599 (+)
AKR/J MGP_AKRJ_G0033446
 protein coding gene Chr8:34402606-34455655 (+)
BALB/cJ MGP_BALBcJ_G0033518
 protein coding gene Chr8:33482805-33536660 (+)
C3H/HeJ MGP_C3HHeJ_G0033230
 protein coding gene Chr8:34758855-34813125 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034034
 protein coding gene Chr8:36038404-36097115 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030983
 protein coding gene Chr8:30314995-30368082 (+)
CAST/EiJ MGP_CASTEiJ_G0032557
 protein coding gene Chr8:34235129-34288822 (+)
CBA/J MGP_CBAJ_G0033208
 protein coding gene Chr8:37448124-37501148 (+)
DBA/2J MGP_DBA2J_G0033361
 protein coding gene Chr8:33296208-33349724 (+)
FVB/NJ MGP_FVBNJ_G0033306
 protein coding gene Chr8:32952098-33005078 (+)
LP/J MGP_LPJ_G0033451
 protein coding gene Chr8:34704421-34757590 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033348
 protein coding gene Chr8:36872791-36926896 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034053
 protein coding gene Chr8:34542677-34597059 (+)
PWK/PhJ MGP_PWKPhJ_G0032267
 protein coding gene Chr8:32854645-32907729 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032099
 protein coding gene Chr8:33787747-33841122 (+)
WSB/EiJ MGP_WSBEiJ_G0032673
 protein coding gene Chr8:34730693-34786340 (+)



Homology
more
  • Human Ortholog
    PRAG1, PEAK1 related, kinase-activating pseudokinase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRAG1, PEAK1 related, kinase-activating pseudokinase 1
  • Synonyms
    NACK, PEAK2, PRAGMIN, SGK223
  • Links
    NCBI Gene ID: 157285
    neXtProt AC: NX_Q86YV5
    UniProt: Q86YV5

  • Chr Location
    8p23.1; chr8:8317736-8386439 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene leads to complete embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    4
  • cDNA Data
    28
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 244418 NCBI Gene Model | MGI Sequence Detail 52925 C57BL/6J ±  kb
transcript NM_001426572 RefSeq | MGI Sequence Detail 4764 C57BL/6  
polypeptide Q571I4 UniProt | EBI | MGI Sequence Detail 1373 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014793 inactive tyrosine-protein kinase PRAG1
    (term hierarchy)
  • InterPro Domains
    IPR051511 Mitochondrial Quality Control and Scaffold Kinases
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008266 Tyrosine-protein kinase, active site
  • GlyGen
    Q571I4 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)
Molecular
Reagents
less
  • All nucleic 32
    cDNA 30
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory