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Zc3h12a Gene Detail
Summary
  • Symbol
    Zc3h12a
  • Name
    zinc finger CCCH type containing 12A
  • Synonyms
    Mcpip1, MGC:41320
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385891
    NCBI Gene: 230738
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:125012216-125021633 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 58.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    254 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385891
 protein coding gene Chr4:125012207-125021674 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028765
 protein coding gene Chr4:126707202-126716618 (-)
A/J MGP_AJ_G0028724
 protein coding gene Chr4:121724108-121733524 (-)
AKR/J MGP_AKRJ_G0028677
 protein coding gene Chr4:125059647-125069089 (-)
BALB/cJ MGP_BALBcJ_G0028747
 protein coding gene Chr4:122313181-122322597 (-)
C3H/HeJ MGP_C3HHeJ_G0028461
 protein coding gene Chr4:125141152-125150568 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029189
 protein coding gene Chr4:131570862-131580279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026462
 protein coding gene Chr4:114888938-114898568 (-)
CAST/EiJ MGP_CASTEiJ_G0027894
 protein coding gene Chr4:123204232-123223953 (-)
CBA/J MGP_CBAJ_G0028427
 protein coding gene Chr4:134847633-134857049 (-)
DBA/2J MGP_DBA2J_G0028576
 protein coding gene Chr4:122193829-122203245 (-)
FVB/NJ MGP_FVBNJ_G0028543
 protein coding gene Chr4:120827074-120836490 (-)
LP/J MGP_LPJ_G0028677
 protein coding gene Chr4:126988219-126997635 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028569
 protein coding gene Chr4:139824611-139834027 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029227
 protein coding gene Chr4:125412629-125422078 (-)
PWK/PhJ MGP_PWKPhJ_G0027615
 protein coding gene Chr4:118619062-118635758 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027441
 protein coding gene Chr4:121205743-121215148 (-)
WSB/EiJ MGP_WSBEiJ_G0027974
 protein coding gene Chr4:125496432-125505851 (-)



Homology
more
  • Human Ortholog
    ZC3H12A, zinc finger CCCH-type containing 12A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZC3H12A, zinc finger CCCH-type containing 12A
  • Synonyms
    dJ423B22.1, MCPIP, MCPIP-1, MCPIP1, Reg1
  • Links
    NCBI Gene ID: 80149
    neXtProt AC: NX_Q5D1E8
    UniProt: Q5D1E8

  • Chr Location
    1p34.3; chr1:37474580-37484377 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Zc3h12a mouse models; 1 with human ZC3H12A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 4 alleles in 5 genetic backgrounds
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit splenomegaly, lymphadenopathy, hyperimmunoglobulinemia, increased auto-antibodies, and defective IL6 post-transcriptional regulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    136
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    16
  • cDNA Data
    18
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042677 Ensembl Gene Model | MGI Sequence Detail 9418 C57BL/6J ±  kb
    transcript ENSMUST00000036188 Ensembl | MGI Sequence Detail 2755 Not Applicable  
    polypeptide ENSMUSP00000037172 Ensembl | MGI Sequence Detail 596 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 2
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 20
      Phenotypes 63
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:358934 Szukala W, et al., Keratinocyte and myeloid MCPIP1 have distinct roles in maintaining skin homeostasis. Biochim Biophys Acta Gen Subj. 2024 Oct;1868(10):130671
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory