Kansl1l MGI Mouse Gene Detail - MGI:1915941 - KAT8 regulatory NSL complex subunit 1-like

Symbol

Kansl1l
Name

KAT8 regulatory NSL complex subunit 1-like
Synonyms

1110028C15Rik, C430010P07Rik

Feature Type

protein coding gene
IDs

MGI:1915941
NCBI Gene: 68691
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:66758407-66856721 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 33.61 cM
Mapping Data

3 experiments

SNPs within 2kb

806 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915941	protein coding gene	Chr1:66758402-66856754 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016115	protein coding gene	Chr1:66981227-67075390 (-)
A/J	MGP_AJ_G0016098	protein coding gene	Chr1:64610480-64705283 (-)
AKR/J	MGP_AKRJ_G0016055	protein coding gene	Chr1:66456339-66551824 (-)
BALB/cJ	MGP_BALBcJ_G0016053	protein coding gene	Chr1:64684629-64784386 (-)
C3H/HeJ	MGP_C3HHeJ_G0015884	protein coding gene	Chr1:66707321-66803249 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016506	protein coding gene	Chr1:69564590-69667242 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014227	protein coding gene	Chr1:60544598-60636272 (-)
CAST/EiJ	MGP_CASTEiJ_G0015468	protein coding gene	Chr1:65942975-66050413 (-)
CBA/J	MGP_CBAJ_G0015857	protein coding gene	Chr1:71815191-71921684 (-)
DBA/2J	MGP_DBA2J_G0015958	protein coding gene	Chr1:64000983-64096349 (-)
FVB/NJ	MGP_FVBNJ_G0015961	protein coding gene	Chr1:63252949-63347795 (-)
LP/J	MGP_LPJ_G0016030	protein coding gene	Chr1:67925908-68022496 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015981	protein coding gene	Chr1:74793313-74901714 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016553	protein coding gene	Chr1:66410549-66506725 (-)
PWK/PhJ	MGP_PWKPhJ_G0015255	protein coding gene	Chr1:63395882-63495657 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015034	protein coding gene	Chr1:65869687-65969607 (-)
WSB/EiJ	MGP_WSBEiJ_G0015530	protein coding gene	Chr1:66134906-66235247 (-)

Human Ortholog

KANSL1L, KAT8 regulatory NSL complex subunit 1 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KANSL1L, KAT8 regulatory NSL complex subunit 1 like
Synonyms

C2orf67, MSL1v2
Links

HGNC:26310

NCBI Gene ID: 151050

neXtProt AC: NX_A0AUZ9

UniProt: A0AUZ9
Chr Location

2q34; chr2:210021421-210172760 (-) GRCh38

MGI Vertebrate Homology

Kansl1l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KANSL1L
Gene Tree

Kansl1l

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Kansl1l
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kansl1l

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All Sequences

132
RefSeq

81
UniProt

4
CCDS

CCDS35603.1

Ensembl

ENSMUSG00000026004 (Evidence)
NCBI Gene

68691

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026004	Ensembl Gene Model \| MGI Sequence Detail	98315	C57BL/6J	± kb
transcript	ENSMUST00000068168	Ensembl \| MGI Sequence Detail	4459	Not Applicable
polypeptide	ENSMUSP00000063843	Ensembl \| MGI Sequence Detail	947	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031730 KAT8 regulatory NSL complex subunit 1-like protein

(term hierarchy)
InterPro Domains

IPR026180 KAT8 regulatory NSL complex subunit 1

IPR029332 PEHE domain

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All nucleic 16

cDNA 16

Microarray probesets 6

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MGI:2138231, MGI:3041218

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:353360 Cesari E, et al., Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development. Nucleic Acids Res. 2024 May 8;52(8):4167-4184

TSS for Kansl1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12005	Chr1:66856760-66856776 (-)	-47 bp
Tssr12004	Chr1:66856695-66856759 (-)	-6 bp
Tssr11999	Chr1:66821398-66821402 (-)	35,321 bp
Tssr11997	Chr1:66804243-66804246 (-)	52,476 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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