Sfmbt2 MGI Mouse Gene Detail - MGI:2447794 - Scm-like with four mbt domains 2

Symbol

Sfmbt2
Name

Scm-like with four mbt domains 2
Synonyms

D2Wsu23e, D330030P06Rik

Feature Type

protein coding gene
IDs

MGI:2447794
NCBI Gene: 353282
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr2:10375321-10600064 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 7.81 cM
Mapping Data

3 experiments

SNPs within 2kb

5561 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447794	protein coding gene	Chr2:10375251-10600064 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025341	protein coding gene	Chr2:7724655-7950607 (+)
A/J	MGP_AJ_G0025318	protein coding gene	Chr2:7389659-7617655 (+)
AKR/J	MGP_AKRJ_G0025287	protein coding gene	Chr2:7632652-7869619 (+)
BALB/cJ	MGP_BALBcJ_G0025314	protein coding gene	Chr2:7393246-7599291 (+)
C3H/HeJ	MGP_C3HHeJ_G0025074	protein coding gene	Chr2:7592564-7802347 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025756	protein coding gene	Chr2:7930072-8155302 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023170	protein coding gene	Chr2:6903276-7115286 (+)
CAST/EiJ	MGP_CASTEiJ_G0024537	protein coding gene	Chr2:7617030-7830923 (+)
CBA/J	MGP_CBAJ_G0025053	protein coding gene	Chr2:8263898-8500082 (+)
DBA/2J	MGP_DBA2J_G0025185	protein coding gene	Chr2:7322572-7544948 (+)
FVB/NJ	MGP_FVBNJ_G0025147	protein coding gene	Chr2:7269362-7489597 (+)
LP/J	MGP_LPJ_G0025271	protein coding gene	Chr2:7613213-7868197 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025179	protein coding gene	Chr2:8206016-8449887 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025814	protein coding gene	Chr2:7583014-7810426 (+)
PWK/PhJ	MGP_PWKPhJ_G0024288	protein coding gene	Chr2:7314649-7518258 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024088	protein coding gene	Chr2:7584965-7791812 (+)
WSB/EiJ	MGP_WSBEiJ_G0024607	protein coding gene	Chr2:7672921-7908818 (+)

Human Ortholog

SFMBT2, Scm like with four mbt domains 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SFMBT2, Scm like with four mbt domains 2
Links

HGNC:20256

NCBI Gene ID: 57713

neXtProt AC: NX_Q5VUG0

UniProt: Q5VUG0
Chr Location

10p14; chr10:7158624-7411490 (-) GRCh38

MGI Vertebrate Homology

Sfmbt2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SFMBT2
Gene Tree

Sfmbt2

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Phenotype Summary

19 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Endonuclease-mediated

6
Gene trapped

25
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

744
Tissues

24
cDNA Data

65
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sfmbt2

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All Sequences

89
RefSeq

30
UniProt

5
CCDS

CCDS38046.1, CCDS57152.1, CCDS57153.1

Ensembl

ENSMUSG00000061186 (Evidence)
NCBI Gene

353282

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061186	Ensembl Gene Model \| MGI Sequence Detail	224744	C57BL/6J	± kb
transcript	ENSMUST00000041105	Ensembl \| MGI Sequence Detail	7874	Not Applicable
polypeptide	ENSMUSP00000040575	Ensembl \| MGI Sequence Detail	975	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000030785 Scm-like with four MBT domains protein 2

(term hierarchy)
InterPro Domains

IPR004092 Mbt repeat

IPR050548 Polycomb group and chromatin remodeling factors

IPR037604 Scm-like with four MBT domains protein 1/2, SAM domain

IPR047353 Scm-like with four MBT domains protein 2, first MBT repeat

IPR047355 Scm-like with four MBT domains protein 2, fourth MBT repeat

IPR047354 Scm-like with four MBT domains protein 2, third MBT repeat

IPR021987 SLED domain

IPR038348 SLED domain superfamily

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

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All nucleic 67

cDNA 65

Primer pair 2

Microarray probesets 3

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MGD-MRK-34243, MGI:106549, MGI:2444880

Summaries

All 49

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 16
Earliest

J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sfmbt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16083	Chr2:10375305-10375328 (+)	-4 bp
Tssr16084	Chr2:10376076-10376099 (+)	767 bp
Tssr16085	Chr2:10376162-10376166 (+)	843 bp
Tssr16086	Chr2:10376420-10376425 (+)	1,102 bp
Tssr16087	Chr2:10377147-10377158 (+)	1,832 bp
Tssr16088	Chr2:10377237-10377308 (+)	1,952 bp
Tssr16089	Chr2:10377362-10377375 (+)	2,048 bp
Tssr16090	Chr2:10385362-10385367 (+)	10,044 bp
Tssr16091	Chr2:10444686-10444690 (+)	69,367 bp
Tssr16092	Chr2:10453895-10453915 (+)	78,584 bp
Tssr16093	Chr2:10528122-10528132 (+)	152,806 bp
Tssr16094	Chr2:10597988-10598002 (+)	222,674 bp
Tssr16095	Chr2:10599672-10599680 (+)	224,355 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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