Dcdc2a MGI Mouse Gene Detail - MGI:2652818 - doublecortin domain containing 2a

Symbol

Dcdc2a
Name

doublecortin domain containing 2a
Synonyms

Dcdc2, MGC:54817, RU2

Feature Type

protein coding gene
IDs

MGI:2652818
NCBI Gene: 195208
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr13:25239987-25394689 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 10.89 cM
Mapping Data

2 experiments

SNPs within 2kb

4510 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2652818	protein coding gene	Chr13:25239126-25394689 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020387	protein coding gene	Chr13:22559660-22713729 (+)
A/J	MGP_AJ_G0020336	protein coding gene	Chr13:22140819-22306320 (+)
AKR/J	MGP_AKRJ_G0020316	protein coding gene	Chr13:22385311-22549956 (+)
BALB/cJ	MGP_BALBcJ_G0020334	protein coding gene	Chr13:22121543-22285672 (+)
C3H/HeJ	MGP_C3HHeJ_G0020138	protein coding gene	Chr13:22448719-22606324 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020771	protein coding gene	Chr13:23357841-23516744 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018359	protein coding gene	Chr13:20843694-20998899 (+)
CAST/EiJ	MGP_CASTEiJ_G0019655	protein coding gene	Chr13:22169655-22335791 (+)
CBA/J	MGP_CBAJ_G0020092	protein coding gene	Chr13:24253930-24422632 (+)
DBA/2J	MGP_DBA2J_G0020218	protein coding gene	Chr13:21640963-21799376 (+)
FVB/NJ	MGP_FVBNJ_G0020202	protein coding gene	Chr13:21276379-21433563 (+)
LP/J	MGP_LPJ_G0020291	protein coding gene	Chr13:22859017-23019538 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020229	protein coding gene	Chr13:24485160-24645735 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020813	protein coding gene	Chr13:22240850-22402573 (+)
PWK/PhJ	MGP_PWKPhJ_G0019409	protein coding gene	Chr13:21642776-21803137 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019225	protein coding gene	Chr13:21061229-21234599 (+)
WSB/EiJ	MGP_WSBEiJ_G0019715	protein coding gene	Chr13:22394250-22566682 (+)

Human Ortholog

DCDC2, doublecortin domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCDC2, doublecortin domain containing 2
Synonyms

DCDC2A, DFNB66, NPHP19, NSC, RU2, RU2S
Links

HGNC:18141

NCBI Gene ID: 51473

neXtProt AC: NX_Q9UHG0

UniProt: Q9UHG0
Chr Location

6p22.3; chr6:24171755-24383292 (-) GRCh38

MGI Vertebrate Homology

Dcdc2a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCDC2
Gene Tree

Dcdc2a

Diseases

5 with human DCDC2 associations

				Human Disease	Mouse Models
				attention deficit hyperactivity disorder IDs attention deficit hyperactivity disorder DOID:1094 DOID:1093 EFO:0003888 ICD9CM:314.8 MESH:D001289 OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312 UMLS_CUI:C0041671
				autosomal recessive nonsyndromic deafness 66 IDs autosomal recessive nonsyndromic deafness 66 DOID:0110517 ICD10CM:H90.3 OMIM:610212
				dyslexia IDs dyslexia DOID:4428 ICD10CM:F81.0 MESH:D004410 NCI:C96410 OMIM:300509 OMIM:600202 OMIM:604254 OMIM:606616 OMIM:606896 OMIM:608995 UMLS_CUI:C0476254
				nephronophthisis 19 IDs nephronophthisis 19 DOID:0111126 OMIM:616217
				sclerosing cholangitis IDs sclerosing cholangitis DOID:14268 EFO:0004268 ICD10CM:K83.09 MESH:D015209 UMLS_CUI:C0008313

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Dcdc2a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

50 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired short term object recognition, impaired visuo-spatial learning and memory and increased anxiety-related response.

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All GO Annotations

39
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

30
cDNA Data

14
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcdc2

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All Sequences

51
RefSeq

18
UniProt

2
CCDS

CCDS26386.2, CCDS56873.1

Ensembl

ENSMUSG00000035910 (Evidence)
NCBI Gene

195208

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035910	Ensembl Gene Model \| MGI Sequence Detail	154703	C57BL/6J	± kb
transcript	ENSMUST00000069614	Ensembl \| MGI Sequence Detail	6634	Not Applicable
polypeptide	ENSMUSP00000063650	Ensembl \| MGI Sequence Detail	475	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032228 doublecortin domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR049626 DCX/DCDC2-like

IPR003533 Doublecortin domain

IPR033036 Doublecortin domain-containing protein 2, doublecortin-like domain 2

IPR036572 Doublecortin domain superfamily

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All nucleic 17

cDNA 14

Primer pair 2

Other 1

Microarray probesets 3

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MGI:2145433

Summaries

All 49

Developmental Gene Expression 7

Gene Ontology 11

Phenotypes 15
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Dcdc2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118997	Chr13:25239261-25239280 (+)	-716 bp
Tssr118998	Chr13:25239447-25239480 (+)	-523 bp
Tssr118999	Chr13:25239947-25239958 (+)	-34 bp
Tssr119000	Chr13:25240027-25240037 (+)	45 bp
Tssr119001	Chr13:25240138-25240188 (+)	176 bp
Tssr119002	Chr13:25240189-25240202 (+)	209 bp
Tssr119003	Chr13:25258674-25258704 (+)	18,702 bp
Tssr119004	Chr13:25258731-25258739 (+)	18,748 bp
Tssr119005	Chr13:25281558-25281562 (+)	41,573 bp
Tssr119006	Chr13:25311234-25311240 (+)	71,250 bp
Tssr119007	Chr13:25335705-25335728 (+)	95,730 bp
Tssr119008	Chr13:25371421-25371439 (+)	131,443 bp
Tssr119009	Chr13:25375864-25375869 (+)	135,880 bp
Tssr119010	Chr13:25392369-25392374 (+)	152,385 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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