Hspb6 MGI Mouse Gene Detail - MGI:2685325 - heat shock protein, alpha-crystallin-related, B6

Symbol

Hspb6
Name

heat shock protein, alpha-crystallin-related, B6
Synonyms

Hsp20

Feature Type

protein coding gene
IDs

MGI:2685325
NCBI Gene: 243912
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:30251961-30254868 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 18.56 cM
Mapping Data

2 experiments

SNPs within 2kb

164 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685325	protein coding gene	Chr7:30251603-30254868 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032026	protein coding gene	Chr7:29557208-29560478 (+)
A/J	MGP_AJ_G0032003	protein coding gene	Chr7:28757123-28760373 (+)
AKR/J	MGP_AKRJ_G0031936	protein coding gene	Chr7:29488841-29492093 (+)
BALB/cJ	MGP_BALBcJ_G0032010	protein coding gene	Chr7:28938630-28941880 (+)
C3H/HeJ	MGP_C3HHeJ_G0031729	protein coding gene	Chr7:29945039-29948307 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032476	protein coding gene	Chr7:30515060-30518328 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029526	protein coding gene	Chr7:29784387-29787698 (+)
CAST/EiJ	MGP_CASTEiJ_G0031063	protein coding gene	Chr7:23200512-23203767 (+)
CBA/J	MGP_CBAJ_G0031695	protein coding gene	Chr7:31968687-31971946 (+)
DBA/2J	MGP_DBA2J_G0031847	protein coding gene	Chr7:28486005-28489260 (+)
FVB/NJ	MGP_FVBNJ_G0031804	protein coding gene	Chr7:28616723-28620447 (+)
LP/J	MGP_LPJ_G0031928	protein coding gene	Chr7:29867137-29870390 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031840	protein coding gene	Chr7:31210158-31213413 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032504	protein coding gene	Chr7:28998270-29001521 (+)
PWK/PhJ	MGP_PWKPhJ_G0030789	protein coding gene	Chr7:23522139-23525390 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030622	protein coding gene	Chr7:20007655-20010908 (+)
WSB/EiJ	MGP_WSBEiJ_G0031173	protein coding gene	Chr7:29384501-29387770 (+)

Human Ortholog

HSPB6, heat shock protein family B (small) member 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSPB6, heat shock protein family B (small) member 6
Synonyms

HEL55, Hsp20, PPP1R91
Links

HGNC:26511

NCBI Gene ID: 126393

neXtProt AC: NX_O14558

UniProt: O14558
Chr Location

19q13.12; chr19:35754566-35758079 (-) GRCh38

MGI Vertebrate Homology

Hspb6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HSPB6
Gene Tree

Hspb6

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

6
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Hspb6
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show increased rates of mortality and ascending aortic rupture in a BAPN-induced thoracic aortic aneurysm and dissection model.

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All GO Annotations

36
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

7
cDNA Data

24
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hspb6

ZFIN hspb6

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All Sequences

43
RefSeq

7
UniProt

2
CCDS

CCDS21097.1

Ensembl

ENSMUSG00000036854 (Evidence)
NCBI Gene

243912

			Length	Strain/Species	Flank
genomic	243912	NCBI Gene Model \| MGI Sequence Detail	2908	C57BL/6J	± kb
transcript	NM_001364179	RefSeq \| MGI Sequence Detail	1637	C57BL/6
polypeptide	Q5EBG6	UniProt \| EBI \| MGI Sequence Detail	162	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008818 heat shock protein beta-6

(term hierarchy)
InterPro Domains

IPR002068 Alpha crystallin/Hsp20 domain

IPR003090 Alpha-crystallin, N-terminal

IPR001436 Alpha crystallin/Small heat shock protein, animal type

IPR008978 HSP20-like chaperone
GlyGen

Q5EBG6 1 site, 1 O-linked glycan (1 site)

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All nucleic 25

cDNA 25

Microarray probesets 3

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MGI:3035329

Summaries

All 47

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 9
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:347876 Gao S, et al., HSPB6 Deficiency Promotes the Development of Aortic Dissection and Rupture. Lab Invest. 2024 Mar;104(3):100326

TSS for Hspb6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65779	Chr7:30251957-30251989 (+)	12 bp
Tssr65780	Chr7:30252688-30252697 (+)	732 bp
Tssr65781	Chr7:30252718-30252734 (+)	765 bp
Tssr65782	Chr7:30254197-30254219 (+)	2,247 bp
Tssr65783	Chr7:30254272-30254285 (+)	2,318 bp
Tssr65784	Chr7:30254296-30254309 (+)	2,342 bp
Tssr65785	Chr7:30254348-30254364 (+)	2,395 bp
Tssr65786	Chr7:30254366-30254377 (+)	2,411 bp
Tssr65787	Chr7:30254460-30254472 (+)	2,505 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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