Ermn MGI Mouse Gene Detail - MGI:1925017

Symbol

Ermn
Name

ermin, ERM-like protein
Synonyms

A330104H05Rik

Feature Type

protein coding gene
IDs

MGI:1925017
NCBI Gene: 77767
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:57935125-57942876 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 32.99 cM, cytoband C2
Mapping Data

3 experiments

SNPs within 2kb

349 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925017	protein coding gene	Chr2:57874920-57942962 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025746	protein coding gene	Chr2:57581210-57590011 (-)
A/J	MGP_AJ_G0025722	protein coding gene	Chr2:55378571-55386365 (-)
AKR/J	MGP_AKRJ_G0025692	protein coding gene	Chr2:56907568-56915372 (-)
BALB/cJ	MGP_BALBcJ_G0025717	protein coding gene	Chr2:55473462-55482734 (-)
C3H/HeJ	MGP_C3HHeJ_G0025478	protein coding gene	Chr2:56981829-56990585 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026163	protein coding gene	Chr2:59328183-59336010 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023569	protein coding gene	Chr2:52974075-52981737 (-)
CAST/EiJ	MGP_CASTEiJ_G0024943	protein coding gene	Chr2:56998129-57006001 (-)
CBA/J	MGP_CBAJ_G0025458	protein coding gene	Chr2:61523999-61535667 (-)
DBA/2J	MGP_DBA2J_G0025589	protein coding gene	Chr2:54993470-55001406 (-)
FVB/NJ	MGP_FVBNJ_G0025551	protein coding gene	Chr2:54526599-54534500 (-)
LP/J	MGP_LPJ_G0025677	protein coding gene	Chr2:57452528-57460322 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025582	protein coding gene	Chr2:63251442-63259211 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026221	protein coding gene	Chr2:56876319-56884073 (-)
PWK/PhJ	MGP_PWKPhJ_G0024684	protein coding gene	Chr2:54819094-54827236 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024490	protein coding gene	Chr2:57003326-57011029 (-)
WSB/EiJ	MGP_WSBEiJ_G0025010	protein coding gene	Chr2:57177600-57188274 (-)

Human Ortholog

ERMN, ermin

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ERMN, ermin
Synonyms

JN, KIAA1189
Links

HGNC:29208

NCBI Gene ID: 57471

neXtProt AC: NX_Q8TAM6

UniProt: Q8TAM6
Chr Location

2q24.1; chr2:157318631-157327713 (-) GRCh38

MGI Vertebrate Homology

Ermn stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ERMN
Gene Tree

Ermn

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

1
Genomic Mutations

1 involving Ermn
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired coordination and demyelination in aged mice with impaired oligodendrocyte differentiation.

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All GO Annotations

31
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

14
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

8
UniProt

1
CCDS

CCDS16047.1

Ensembl

ENSMUSG00000026830 (Evidence)
NCBI Gene

77767

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026830	Ensembl Gene Model \| MGI Sequence Detail	7752	C57BL/6J	± kb
transcript	ENSMUST00000090940	Ensembl \| MGI Sequence Detail	3635	Not Applicable
polypeptide	ENSMUSP00000088458	Ensembl \| MGI Sequence Detail	281	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007183 ermin

(term hierarchy)
InterPro Domains

IPR045346 Ermin

IPR008954 Moesin tail domain superfamily
GlyGen

Q5EBJ4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 14

cDNA 14

Microarray probesets 5

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MGI:2139104

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ermn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr24131	Chr2:57942844-57942882 (-)	13 bp
Tssr24130	Chr2:57942822-57942841 (-)	44 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24